Results 61 to 70 of about 908,561 (333)

The key role of nitric oxide in hypoxia: hypoxic vasodilation and energy supply-demand matching [PDF]

, 2013
Significance: a mismatch between energy supply and demand induces tissue hypoxia with the potential to cause cell death and organ failure. Whenever arterial oxygen concentration is reduced, increases in blood flow - 'hypoxic vasodilation' - occur in an ...
Alex Dyson, Audibert G, Berne RM, Blitzer ML, Boutilier RG, Brown IP, Devlin C, Furukawa K, Hall JE, Heyes MP, Jekabsone A, Lehninger A, Leone AM, Louis CA, Martin Feelisch, Mervyn Singer, Michele Umbrello, Modin A, Munk VC, Pohl U, Rengasamy A, Rengasamy A, Vallance P, Whorton AR   +23 more
core   +1 more source

Early Physiological and Neurological Monitoring after Traumatic Brain Injury as Foundations for Outcome Prediction: A Narrative Review

Bali Journal of Anesthesiology
Early physiological and neurological monitoring provides the first opportunity to identify and modify the determinants of outcome after traumatic brain injury.
Christopher Ryalino, Andrea Gentile, Putu Herdita Sudiantara, Tjokorda Gde Bagus Mahadewa   +3 more
doaj   +1 more source

Evaluation of patient response and recurrence of pigmentation following gingival depigmentation using laser and scalpel technique: A clinical study

Journal of Indian Society of Periodontology, 2014
Aim: The present study was undertaken to evaluate patient response and recurrence of pigmentation following gingival depigmentation carried out with a surgical blade and diode laser.
Harpreet Singh Grover, Himanshu Dadlani, Amit Bhardwaj, Anil Yadav, Sanjay Lal   +4 more
doaj   +1 more source

An intracellular transporter mitigates the CO2‐induced decline in iron content in Arabidopsis shoots

FEBS Letters, EarlyView.
This study identifies a gene encoding a transmembrane protein, MIC, which contributes to the reduction of shoot Fe content observed in plants under elevated CO2. MIC is a putative Fe transporter localized to the Golgi and endosomal compartments. Its post‐translational regulation in roots may represent a potential target for improving plant nutrition ...
Timothy Mozzanino, Meijie Li, Cécile Fizames, Mattia Adamo, Laurence Lejay, Christian Dubos, Matthieu Platre, Antoine Martin   +7 more
wiley   +1 more source

A Physiologically-Based Pharmacokinetic Simulation to Evaluate Approaches to Mitigate Efavirenz-Induced Decrease in Levonorgestrel Exposure with a Contraceptive Implant

Pharmaceutics
Background: Levonorgestrel implant is a highly effective hormonal contraceptive, but its efficacy may be compromised when used with cytochrome enzyme inducers such as efavirenz. The primary aim of this study was to evaluate methods of mitigating the drug
Lilian W. Adeojo, Rena C. Patel, Nancy C. Sambol   +2 more
doaj   +1 more source

CB1R and iNOS are distinct players promoting pulmonary fibrosis in Hermansky–Pudlak syndrome

Clinical and Translational Medicine, 2021
Hermansky–Pudlak syndrome (HPS) is a rare genetic disorder which, in its most common and severe form, HPS‐1, leads to fatal adult‐onset pulmonary fibrosis (PF) with no effective treatment.
Resat Cinar, Joshua K. Park, Charles N. Zawatsky, Nathan J. Coffey, Steven P. Bodine, Jasmina Abdalla, Tadafumi Yokoyama, Tony Jourdan, Lindsey Jay, Mei Xing G. Zuo, Kevin J. O'Brien, Junfeng Huang, Ken Mackie, Asaf Alimardanov, Malliga R. Iyer, William A. Gahl, George Kunos, Bernadette R. Gochuico, May Christine V. Malicdan   +18 more
doaj   +1 more source

Oropharyngeal microbiome profiled at admission is predictive of the need for respiratory support among COVID-19 patients

Frontiers in Microbiology, 2022
The oropharyngeal microbiome, the collective genomes of the community of microorganisms that colonizes the upper respiratory tract, is thought to influence the clinical course of infection by respiratory viruses, including Severe Acute Respiratory ...
Evan S. Bradley, Evan S. Bradley, Abigail L. Zeamer, Abigail L. Zeamer, Vanni Bucci, Vanni Bucci, Lindsey Cincotta, Marie-Claire Salive, Protiva Dutta, Shafik Mutaawe, Otuwe Anya, Christopher Tocci, Ann Moormann, Doyle V. Ward, Doyle V. Ward, Beth A. McCormick, Beth A. McCormick, John P. Haran, John P. Haran, John P. Haran   +19 more
doaj   +1 more source

A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins

FEBS Letters, EarlyView.
We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue, Sandrine Picaud, Régine Hepp, Stéphanie Pons, Uwe Maskos, Bertrand Lambolez, Ludovic Tricoire   +6 more
wiley   +1 more source

Investigation of Lower-limb Tissue Perfusion during Loading [PDF]

, 2002
An extant tissue indentor used for amputee residual limb tissue indentation studies was modified to include laser Doppler flowmetry (LDF) to enable measurement of tissue perfusion during indentation.
Silver-Thorn, Barbara
core   +1 more source

Impact of a Workplace Stress Reduction Program on Blood Pressure and Emotional Health in Hypertensive Employees [PDF]

, 2003
This study examined the impact of a workplace-based stress management program on blood pressure (BP), emotional health, and workplace-related measures in hypertensive employees of a global information technology ...
Dana Tomasino, Mike Atkinson, Rollin McCraty   +2 more
core   +1 more source