Results 31 to 40 of about 133,198 (274)

Serum Myonectin Levels Are Positively Associated With Physical Function and Lower Frailty‐Related Limitation in Maintenance Hemodialysis Patients: A Cross‐Sectional Study

open access: yesTherapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Maintenance hemodialysis (MHD) patients frequently suffer from frailty, characterized by reduced physical function and poor prognosis. Myokines, such as myonectin, secreted by muscle, are emerging regulators of systemic health. This study investigated the relationship between serum myonectin, adipokines (adiponectin, omentin), and ...
Kenichi Kono   +7 more
wiley   +1 more source

Physiologic specialisation in Piricularia oryzae Cav. [PDF]

open access: yes, 1967
The existence of physiologic races in Piricularia oryzae Cav., the causal fungus of blast disease, has been established in India. Sixteen races and three biotypes were distinguished out of 19 isolates tested.
Veeraraghavan, J.   +3 more
core   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

open access: yesFEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi   +6 more
wiley   +1 more source

PHYSIOLOGIC RACES OF PUCCINIA GRAMINIS TRITICI IN CANADA, 1919 TO 1944

open access: yes, 1946
During the period 1919 to 1944, 65 physiologic races were identified from a total of 4543 isolates derived from uredial collections of Puccinia graminis Pers. var. Tritici Erikss. & Henn.
Margaret Newton, T. Johnson
core   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

ADULT PLANT RESISTANCE OF SOME OAT VARIETIES TO PHYSIOLOGIC RACES OF CROWN RUST

open access: yes, 1944
The reactions of five varieties of oats in the seedling and adult plant stages to seven physiologic races of crown rust, Puccinia coronata Corda var. Avenae Erikss. & Henn.
B. Peturson
core   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

open access: yesFEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante   +10 more
wiley   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

open access: yesFEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança   +2 more
wiley   +1 more source

CROSSING AND SELFING STUDIES WITH PHYSIOLOGIC RACES OF OAT STEM RUST

open access: yes, 1940
Evidence has been obtained through crossing and selfing studies that some physiologic races of oat stem rust contain both homozygous and heterozygous lines, the latter when selfed tending to produce races more virulent than the selfed race.
Margaret Newton, Thorvaldur Johnson
core   +1 more source

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