Results 111 to 120 of about 806,968 (339)
Phenotypic flexibility and the evolution of organismal design [PDF]
Evolutionary biologists often use phenotypic differences between species and between individuals to gain an understanding of organismal design. The focus of much recent attention has been on developmental plasticity – the environmentally induced ...
Drent, Jan,, Piersma, Theunis,
core +3 more sources
Phenotypic plasticity in a newly established set of EGFR inhibitor‐adapted NSCLC cell lines during adaptation and in established cell lines. Here, we introduce novel sublines of the EGFR‐mutant non‐small cell lung cancer (NSCLC) cell lines HCC827 and HCC4006 adapted to the EGFR kinase inhibitors gefitinib (HCC827rGEFI2μm, HCC4006rGEFI1μm), erlotinib ...
Tharsagini V. Nanthaprakash +6 more
wiley +1 more source
Introduction: The relationship between morphological and psychological parameters and cardiovascular autonomic responses was investigated in experienced cold-water swimmers.
Josefa Lillo Bobadilla +7 more
doaj +1 more source
Standard ecological methods (pitfall traps, trunk eclectors and soil cores) were used to evaluate collembolan community responses to different flooding intensities.
Michael Thomas Marx +5 more
doaj +1 more source
Health in ultra endurance events: SUMMIT Lab® Project [PDF]
High-intensity physical activity for an extended period of time could result in unhealthy disruptions to physiological systems. The main goal of the SUMMIT Lab® is to offer to ultra-endurance athletes an assessment of the impact of training with ...
Bayés Genis, Antoni +7 more
core
A novel model to explain dietary factors affecting hypocalcaemia in dairy cattle [PDF]
Most dairy cows exhibit different degrees of hypocalcaemia around calving because the gestational Ca requirements shift to the disproportionately high Ca requirements of lactation.
Martin-Tereso Lopez, J. +1 more
core +2 more sources
The E3 ubiquitin ligase, RNF219, suppresses CNOT6L expression to exhibit antiproliferative activity
We identified RNF219 as a CCR4‐NOT complex‐interacting E3 ubiquitin ligase that targets the CCR4‐NOT subunit CNOT6L for ubiquitination. RNF219 directly binds to the DUF3819 domain of CNOT1 through its putative α‐helix spanning amino acids 521–542. Our findings also suggest that antiproliferative activity of RNF219 is at least partially mediated by ...
Shou Soeda +9 more
wiley +1 more source
This study investigated the physiological adaptations and functional consequences of a 12-week specialized training program in youth soccer players, focusing on musculoskeletal development, cardiorespiratory responses, and neuromuscular adaptations ...
I. Grygus +4 more
doaj +1 more source
Climate change and temperature dependent biogeography: oxygen limitation of thermal tolerance in animals [PDF]
Recent years have shown a rise in mean global temperatures and a shift in the geographical distribution of ectothermic animals. For a cause and effect analysis the present paper discusses those physiological processes limiting thermal tolerance.
Pörtner, Hans-Otto
core +1 more source
Sphingoid base structures, the sphingolipid backbones, vary among species. We established yeast cells in which the native sphingoid base was replaced with plant‐type bases containing cis or trans double bonds. This is, to our knowledge, the first eukaryotic model mostly composed of sphingolipids containing cis‐unsaturated sphingoid base, providing a ...
Takashi Higuchi +5 more
wiley +1 more source

