Results 71 to 80 of about 116,414 (298)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Affective Videogames and Modes of Affective Gaming: Assist Me, Challenge Me, Emote Me [PDF]

, 2005
In this paper we describe the fundamentals of affective gaming from a physiological point of view, covering some of the origins of the genre, how affective videogames operate and current conceptual and technological capabilities.
Allanson, Jen, Dix, Alan, Gilleade, Kiel
core  

Physiological and Psychological Restoration in Matched Real and Virtual Natural Environments

, 2020
CHI EA '20: Extended Abstracts of the 2020 CHI Conference on Human Factors in Computing SystemsApril 2020Peer ...
Howell O. Istance, Roope Raisamo, Nukarinen, Tomi, Surakka, Veikko, Korpela, Kalevi, Rantala, Jussi, Tomi Nukarinen, Veikko Surakka, Raisamo, Roope, Kalevi Korpela, Ronkainen, Kimmo, John Mäkelä, Jussi Rantala, Kimmo Ronkainen, Istance, Howell, Mäkelä, John   +15 more
core   +1 more source

Electron transfer between complexes III and IV in S. cerevisiae mitochondrial membranes

FEBS Letters, EarlyView.
Mitochondrial oxidative phosphorylation in S. cerevisiae mitoplasts is limited by complex IV catalytic capacity, rather than two‐dimensional cytochrome c diffusion. At physiological cytochrome c : supercomplex ratios at salinity equivalent to that of 20 mm monovalent salt, activity is maximized, indicating that this low ionic strength accurately mimics
Ana Paula Lobez, Mikael Oliveberg, Peter Brzezinski   +2 more
wiley   +1 more source

SIG PhysioCHI: Human-centered physiological computing in practice [PDF]

In recent years, integrating physiological signals in Human-Computer Interaction research has significantly advanced our understanding of user experiences and interactions.
Niijima, A. (Arinobu), Solovey, E. (Erin), Tag, B. (Benjamin), El Ali, A. (Abdallah), Mitrevska, T. (Teodora), Sidenmark, L. (Ludwig), Mayer, S. (Sven), Perusquía-Hernández, M. (Monica), Chiossi, F. (Francesco)   +8 more
core   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Computational insights in cell physiology

Frontiers in Systems Biology
Physiological processes are governed by intricate networks of transcriptional and post-translational regulations. Inter-cellular interactions and signaling pathways further modulate the response of the cells to environmental conditions. Understanding the dynamics of these systems in healthy conditions and their alterations in pathologic situations ...
Gonze, Didier, Dupont, Geneviève
openaire   +4 more sources

Development of an open affective computing environment

, 2012
Affective computing facilitates more intuitive, natural computer interfaces by enabling the communication of the user’s emotional state. Despite rapid growth in recent years, affective computing is still an under-explored field, which holds promise to be
Thompson, Nik
core   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source