Results 91 to 100 of about 1,543,308 (302)

The normal ranges of cardiovascular parameters measured using the ultrasonic cardiac output monitor [PDF]

, 2017
The ultrasonic cardiac output monitor (USCOM) is a noninvasive transcutaneous continuous wave Doppler method for assessing hemodynamics. There are no published reference ranges for normal values in adults (aged 18– 60 years) for this device.
Cattermole, Giles N, Chan, Cangel P.Y, Chan, Stewart S.W, Graham, Colin A, Ho, Grace Y.L, Lau, Peach W.S, Leung, P.Y Mia, Rainer, Timothy H, Smith, Brendan E   +8 more
core   +3 more sources

Variational theory for physiological flow

Computers & Mathematics with Applications, 2007
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +2 more sources

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Temperature-dependent release of ATP from human erythrocytes: Mechanism for the control of local tissue perfusion [PDF]

, 2012
Copyright @ 2012 The AuthorsThis article has been made available through the Brunel Open Access Publishing Fund.Human limb muscle and skin blood flow increases significantly with elevations in temperature, possibly through physiological processes that ...
Abraham, Akyurekli, Baar, Barcroft, Bazett, Bergfeld, Black, Cheng, Coade, Cripps, Denning, Deussen, Dill, Duc, Dufour, Ellsworth, Feliciano, Fischer, González-Alonso, González-Alonso, González-Alonso, Gordon, Gorman, Gorman, Gourine, Green, He, José González-Alonso, Kameljit K. Kalsi, Keller, Kirby, Kirby, Llaudet, Locovei, Malinauskas, Mortensen, Mortensen, Mortensen, Niimi, Olearczyk, Pearson, Ray, Rosenmeier, Rowell, Ruiter, Saltin, Schrage, Scott-Ward, Sheppard, Sprague, Sprague, Sridharan, Sterling, Tu, Williamson, Yegutkin, Yegutkin, Zimmermann, Zimmermann   +58 more
core   +2 more sources

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

LES of non-newtonian physiological blood flow [PDF]

, 2009
Large Eddy Simulation (LES) is performed to study the physiological pulsatile transition to turbulent non-Newtonian blood flow through a 3D model of arterial stenosis using the different non-Newtonian blood viscosity models.
Molla, M.M., Paul, M.C.
core  

Renal pericytes: regulators of medullary blood flow [PDF]

, 2012
Regulation of medullary blood flow (MBF) is essential in maintaining normal kidney function. Blood flow to the medulla is supplied by the descending vasa recta (DVR), which arise from the efferent arterioles of juxtamedullary glomeruli.
Agmon Y., Beach R.E., Biondi M., Burnstock G., Casellas D., Cohen H.J., Edwards R.M., Guan Z., Harrison‐Bernard L.M., Harrison‐Bernard L.M., Jamison R.L., Kreisberg M.S., Kriz W., Larson T.S., Lazarowski E.R., Lerman L.O., Majid D.S., Pallone T.L., Rouget C., Seldin D.W., Stern M.D., Strick D.M., Takenaka T., Takezawa K., Turner M.R., Unwin R.J., Yamagishi S., Yang S.   +27 more
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Intracellular oxygen tension limits muscle contraction-induced change in muscle oxygen consumption under hypoxic conditions during Hb-free perfusion. [PDF]

, 2017
Under acute hypoxic conditions, the muscle oxygen uptake (mV˙O2) during exercise is reduced by the restriction in oxygen-supplied volume to the mitochondria within the peripheral tissue. This suggests the existence of a factor restricting the mV˙O2 under
Furuichi, Yasuro, Hashimoto, Takeshi, Iwase, Satoshi, Jue, Thomas, Masuda, Kazumi, Ojino, Minoru, Takakura, Hisashi, Yamada, Tatsuya   +7 more
core   +1 more source