Results 41 to 50 of about 801,084 (264)

Effect of Varying Hemodynamic and Vascular Conditions on Fractional Flow Reserve: An In Vitro Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016
BackgroundThe aim of this study was to investigate the impact of varying hemodynamic conditions on fractional flow reserve (ratio of pressure distal [Pd] and proximal [Pa] to stenosis under hyperemia) in an in vitro setting.
Kranthi K. Kolli, James K. Min, Seongmin Ha, Hilary Soohoo, Guanglei Xiong   +4 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

An Integrated Pulsation-Free, Backflow-Free Micropump Using the Analog Waveform-Driven Braille Actuator

Micromachines, 2022
The widespread adoption of long-term organs-on-a-chip culture necessitates both active perfusions that mimic physiological flow conditions and minimization of the complexity of microfluidic system and fluid handling.
Kotaro Nishikata, Masataka Nakamura, Yuto Arai, Nobuyuki Futai   +3 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

User-friendly microfluidic system reveals native-like morphological and transcriptomic phenotypes induced by shear stress in proximal tubule epithelium

APL Bioengineering, 2023
Drug-induced nephrotoxicity is a leading cause of drug attrition, partly due to the limited relevance of pre-clinical models of the proximal tubule. Culturing proximal tubule epithelial cells (PTECs) under fluid flow to mimic physiological shear stress ...
Natalie N. Khalil, Andrew P. Petersen, Cheng J. Song, Yibu Chen, Kaelyn Takamoto, Austin C. Kellogg, Elaine Zhelan Chen, Andrew P. McMahon, Megan L. McCain   +8 more
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Measuring Flow: Refining Research Protocols That Integrate Physiological and Psychological Approaches

Human Behavior and Emerging Technologies
Measuring flow, an optimal mental state defined by intense focus and immersion, can provide valuable insights into research on human engagement. However, a review of 69 studies identified significant methodological issues that could be undermining ...
Martin Wonders, Dan Hodgson, Nicola Whitton   +2 more
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Physiological predictors Of peak inspiRatory flow using Observed lung function resultS (POROS): evaluation at discharge among patients hospitalized for a COPD exacerbation

International Journal of COPD, 2018
David B Price,1,2 Sen Yang,1 Simon Wan Yau Ming,1 Antony Hardjojo,1 Claudia Cabrera,3,4 Andriana I Papaioannou,5 Stelios Loukides,5 Vicky Kritikos,6 Sinthia Z Bosnic-Anticevich,6 Victoria Carter,7 Paul M Dorinsky8 1Observational and Pragmatic Research ...
Price DB, Yang S, Wan Yau Ming S, Hardjojo A, Cabrera C, Papaioannou AI, Loukides S, Kritikos V, Bosnic-Anticevich SZ, Carter V, Dorinsky PM   +10 more
doaj  

GPR68 Senses Flow and Is Essential for Vascular Physiology [PDF]

Cell, 2018
Mechanotransduction plays a crucial role in vascular biology. One example of this is the local regulation of vascular resistance via flow-mediated dilation (FMD). Impairment of this process is a hallmark of endothelial dysfunction and a precursor to a wide array of vascular diseases, such as hypertension and atherosclerosis.
Xu, Jie, Mathur, Jayanti, Vessières, Emilie, Hammack, Scott, Nonomura, Keiko, Favre, Julie, Grimaud, Linda, Petrus, Matt, Francisco, Allain, Li, Jingyuan, Lee, Van, Xiang, Fu-li, Mainquist, James K, Cahalan, Stuart M, Orth, Anthony P, Walker, John R, Ma, Shang, Lukacs, Viktor, Bordone, Laura, Bandell, Michael, Laffitte, Bryan, Xu, Yan, Chien, Shu, Henrion, Daniel, Patapoutian, Ardem   +24 more
openaire   +4 more sources