Results 61 to 70 of about 801,084 (264)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
MicromachinesRotary Blood Pump (RBP) is a commonly used ventricular assist device. However, the constant speed operation of the blood pump leads to a reduction of blood flow pulsatility, which triggers a series of adverse reactions.
Yanjun Bao +3 more
doaj +1 more source
Frontiers in Human Neuroscience, 2013 Functional Near-Infrared Spectroscopy (fNIRS) is a promising method to study functional organization of the prefrontal cortex. However, in order to realize the high potential of fNIRS, effective discrimination between physiological noise originating from
Evgeniya eKirilina +5 more
doaj +1 more source
Flow of Physiological Fluids in Microchannels: The Sedimentation Effect [PDF]
, 2010 Microfluidic devices are becoming one of the most promising new tools for diagnostic applications and treatment of several chronic diseases. Hence, it is increasingly important to investigate the rheological behaviour of physiological fluids in microchannels.
Garcia, Valdemar +3 more
openaire +4 more sources
THE PHYSIOLOGICAL VARIATIONS IN RESISTANCE TO BILE FLOW TO THE INTESTINE [PDF]
Journal of Experimental Medicine, 1926 Under specially controlled conditions in the healthy unanesthetized dog we have measured the resistance offered to the flow of bile through the lower common duct. The average resistance 4 to 12 hours after a feeding was found to correspond to the pressure of a column of bile 100 to 120 mm. in height.
R, Elman, P D, McMaster
openaire +2 more sources
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Easy Pulsatile Phantom for Teaching and Validation of Flow Measurements in Ultrasound
Ultrasound International Open, 2016 Purpose: To build a simple model to teach and validate non-pulsatile and pulsatile flow quantification in ultrasound. Materials and Methods: The setting consists of the following connected components: (1) medical syringe pump producing an adjustable ...
M. B. Rominger +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
Scientific ReportsThis study aimed to evaluate the sensitivity of AI in screening acute leukemia and its capability to classify either physiological or pathological cells.
Fu-Ming Cheng +6 more
doaj +1 more source