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Microfabricated Physiological Models for In Vitro Drug Screening Applications [PDF]
Micromachines, 2016 Microfluidics and microfabrication have recently been established as promising tools for developing a new generation of in vitro cell culture microdevices.
Giovanni Stefano Ugolini +4 more
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Physiological models of the lateral superior olive. [PDF]
PLoS Computational Biology, 2017 In computational biology, modeling is a fundamental tool for formulating, analyzing and predicting complex phenomena. Most neuron models, however, are designed to reproduce certain small sets of empirical data.
Go Ashida +2 more
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Exploring Deep Physiological Models for Nociceptive Pain Recognition [PDF]
Sensors, 2019 Standard feature engineering involves manually designing measurable descriptors based on some expert knowledge in the domain of application, followed by the selection of the best performing set of designed features for the subsequent optimisation of an ...
Patrick Thiam +3 more
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Sex matters: the frequently overlooked importance of considering sex in computational models
Frontiers in Physiology, 2023 Personalised medicine and the development of a virtual human or a digital twin comprises visions of the future of medicine. To realise these innovations, an understanding of the biology and physiology of all people are required if we wish to apply these ...
K. S. Burrowes +3 more
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Nature Communications, 2022 Targeted therapeutic options for NRAS-mutant melanoma are limited. Here, the authors show that under metabolic stress NRAS-mutant melanoma cells activate a BRAF-dependent glycolysis pathway for survival, leading to improve efficacy of sorafenib when ...
Kimberley McGrail +16 more
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Healthcare Technology Letters, 2023 Preterm birth is a global epidemic affecting millions of mothers across different ethnicities. The cause of the condition remains unknown but has recognised health‐based implications, in addition to financial and economic ones.
Ejay Nsugbe +3 more
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Non‐invasive ventilation treatment for patients with chronic obstructive pulmonary disease
Healthcare Technology Letters, 2023 Chronic obstructive pulmonary disease (COPD) affects the lives of millions of patients worldwide. Patients with advanced COPD may require non‐invasive ventilation (NIV) to support the resultant deficiencies of the respiratory system.
Fleur T. Tehrani, James H. Roum
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Design method for a bionic wrist based on tensegrity structures
Biosurface and Biotribology, 2020 The traditional bionic upper limb structure design is limited by the motion pair and cannot guarantee the flexibility of the mechanical structure. The tensegrity structure has the characteristics of high deformability, strong self-adaptability, and ...
Jianwei Sun, Xuemin Cao, Guangsheng Song
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Impact of different housing models on physiological responses of Saidi ewes under Upper Egyptian conditions [PDF]
Fayoum Journal of Agricultural Research and Development, 2022 A total of 40 Saidi ewes were used approximately 2 years of age and had an average initial body weight (BW) of 40 ± 2.46 kg. Ambient temperature (AT) and relative humidity (RH%) were recorded simultaneously while measuring the physiological responses at ...
Rana, A. +4 more
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In vitro toxicity model: Upgrades to bridge the gap between preclinical and clinical research
Biomolecules & Biomedicine, 2020 The Centers for Disease Control and Prevention (CDC) provides extensive data that indicate our need for drugs to maintain human population health. Despite the substantial availability of drugs on the market, many patients lack specific drugs.
Eneko Madorran +3 more
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