FEBS Open Bio, EarlyView.Lactoferrin promotes wound healing by activating MAPK, PI3K/Akt, and extracellular matrix pathways, enhancing fibroblast remodeling, proliferation, and re‐epithelialization. These mechanisms highlight its therapeutic potential in inflammation control, tissue repair, and remodeling.
Morgana Lüdtke Azevedo +4 more
wiley +1 more source
Integrating vascular microstructure into coronary physiology: Beyond autoregulation. [PDF]
J PhysiolCampo Dall'Orto C.
europepmc +1 more source
FEBS Open Bio, EarlyView.NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks +4 more
wiley +1 more source
Center for Teaching Old Models New Tricks (TOMNET): Data Management Plan (DMP)
This document constitutes a Data Management Plan (DMP) for the Center for Teaching Old Models New Tricks (TOMNET), a US Department of Transportation Tier 1 University Transportation Center (UTC) led by Arizona State University (ASU).
Center for Teaching Old Models New Tricks (TOMNET)
core
STREAM: A data-driven framework for physiological state monitoring in ICU patients. [PDF]
PLOS Digit HealthNamvar A +5 more
europepmc +1 more source
Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model
FEBS Open Bio, EarlyView.This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito +7 more
wiley +1 more source
FEBS Open Bio, EarlyView.KDAC6 has been associated with cell motility and actin structures, but specific domain contributions are not established. The two catalytic domains have differential effects on motility and F‐actin regulation, affecting cortical F‐actin density, motility, stress fibers, and cell spreading.
Taylor V. Joseph +7 more
wiley +1 more source
Early Risk Stratification of Severe Trauma in the Emergency Department: Integrating Clinical Scoring Systems, Dynamic Biomarkers, and Artificial Intelligence-A Narrative Review. [PDF]
Ther Clin Risk ManagSun X, Han J, Ni J, Shen Y.
europepmc +1 more source
Evolution‐guided yeast complementation reveals functional differences in human PSPH variants
FEBS Open Bio, EarlyView.Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez +6 more
wiley +1 more source
A hybrid ML-PBPK digital twin framework for clinically interpretable readmission risk and drug exposure stratification in diabetes. [PDF]
Front Digit HealthAhmed K N, Ibrahim Syed Masood JA.
europepmc +1 more source