Results 221 to 230 of about 8,886,497 (252)

Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells

FEBS Open Bio, EarlyView.
Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla, Martín M. Ledesma, Santiago A. Behr, Matías A. Pibuel, María L. Palanek, Daniel H. Grasso, Maria N. Garcia, Juan Garona, Silvina L. Lompardía, Elida Álvarez, Daniela L. Papademetrio   +10 more
wiley   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Improving physiological monitoring and reporting standards in preclinical stroke research. [PDF]

J Cereb Blood Flow Metab
Premilovac D, Coombe HE, Trotman-Lucas M, Beard DJ, Stuckey SM, Morris GP, Hood RJ.   +6 more
europepmc   +1 more source

Fusing Wearable and Environmental Sensors for Context-Aware Firefighter Wellbeing Monitoring. [PDF]

Sensors (Basel)
Appelle A, Stach E, Boyd B, Salvino L, Lynch JP.   +4 more
europepmc   +1 more source

Physiological reviews

American Physiological Society (1887- )
core  

The Applications and Future Prospects of Organ Medicine. [PDF]

Health Care Sci
Zhang J, Liu Y, Li Y, Hu R, Mo R, Zhang Y, Huang G, He X.   +7 more
europepmc   +1 more source

Multiscale computational modeling to quantify how spiral artery remodeling alters wall shear stress on placental villi. [PDF]

PLoS Comput Biol
Najmi A, Grande Gutiérrez N.
europepmc   +1 more source

Toward robust AI-based ECG R-peak detection for real-time physiological monitoring in operational environments. [PDF]

Front Psychol
Boström M, Jonsäll E, Allenmark F, Amoignon O, Persson E, Elcadi GH.   +5 more
europepmc   +1 more source

Cell Population Dynamics Informed by Cell-Cycle Regulation: A Deterministic Modeling Toolkit. [PDF]

Comput Struct Biotechnol J
Ferro E, Laus A, Atzeni R, Valentini M, Pieroni E, Pisu M.   +5 more
europepmc   +1 more source