Results 231 to 240 of about 31,417,423 (292)

Prediction of pharmacokinetic/pharmacodynamic properties of aldosterone synthase inhibitors at drug discovery stage using an artificial intelligence-physiologically based pharmacokinetic model. [PDF]

Front Pharmacol
Zhang M, Wu K, Long S, Jin X, Liu B.
europepmc   +1 more source

Hederagenin Attenuates Morphine Addiction via GABAA1‐Mediated Modulation of Ca2+–CaMK–CREB Signaling in Ventral Tegmental Dopaminergic Neurons

Advanced Science, EarlyView.
Hederagenin is identified as a GABAA1‐targeting natural compound that suppresses morphine‐associated reward by restraining Ca2+–CaMK–cAMP–CREB signaling in ventral tegmental dopaminergic neurons. RVG29‐modified liposomal delivery further enhances brain accumulation and behavioral efficacy, providing a mechanistically defined strategy for natural ...
Hongyang Jiang, Ziting Zhou, Nannan Xue, Jiasi Deng, Yuanyuan Zhou, Xinying Lv, Yuxuan Wang, Yi Zhang, Haotian Pan, Geyan Xu, Yinkun Tao, Mengran Li, Xin Cui, Hongyue Ma, Qian Wang, Zhigang Lu   +15 more
wiley   +1 more source

A physiologically based pharmacokinetic model of diethyl phthalates in humans. [PDF]

Environ Pollut
Chen S, Shi Z, Zhang Q.
europepmc   +1 more source

Physiologically-based pharmacokinetic model for CAR-T cells delivery and efficacy in solid tumors

Hadjigeorgiou AG, Munn LL, Stylianopoulos T, Jain RK.   +3 more
europepmc   +1 more source

Meta-Analysis of the Input and Disposition of Various Dosage Forms of Methylprednisolone in Healthy Subjects Utilizing a Physiologically Based Pharmacokinetic Model. [PDF]

AAPS J
Yu R, Jusko WJ.
europepmc   +1 more source

Prediction of SPT-07A Pharmacokinetics in Rats, Dogs, and Humans Using a Physiologically-Based Pharmacokinetic Model and In Vitro Data. [PDF]

Pharmaceutics
Zhu X, Kong W, Wang Z, Liu X, Liu L.
europepmc   +1 more source

Development of a physiologically-based pharmacokinetic model to simulate the pharmacokinetics of intramuscular antiretroviral drugs. [PDF]

CPT Pharmacometrics Syst Pharmacol
Bettonte S, Berton M, Battegay M, Stader F, Marzolini C.   +4 more
europepmc   +1 more source

Whole Body Physiologically Based Pharmacokinetic Model to Explain A Patient With Drug-Drug Interaction Between Voriconazole and Flucloxacillin. [PDF]

Eur J Drug Metab Pharmacokinet
Abdullah-Koolmees H, van den Nieuwendijk JF, Hoope SMKT, de Leeuw DC, Franken LGW, Said MM, Seefat MR, Swart EL, Hendrikse NH, Bartelink IH.   +9 more
europepmc   +1 more source

Development of a physiologically-based pharmacokinetic model for Ritonavir characterizing exposure and drug interaction potential at both acute and steady-state conditions. [PDF]

CPT Pharmacometrics Syst Pharmacol
Ngo LT, Jung W, Bui TT, Yun HY, Chae JW, Momper JD.   +5 more
europepmc   +1 more source