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Physiologically Based Pharmacokinetic Modeling
2005Preface. Acknowledgments. Contributors. Chapter 1. Introduction: A Historical Perspective of the Development and Applications of PBPK Models. 1. Introduction. 2. A Historical Perspective. 2-1. Responses to Inhaled Compounds. 2-2. Pharmaceutical Applications. 2-3. Occupational and Environmental Applications. 2-4. Digital Computation and PBPK Modeling. 3.
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Development of a physiologically based pharmacokinetic model of paraquat
2017 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), 2017Paraquat (N, N'-dimethyl-4,4'-bipyridium dichloride) is a potent and widely used herbicide in agricultural countries, including Thailand. The presence of this chemical in the body can lead to toxic effects in the liver, kidney, and lung. Pulmonary toxicity has been identified as the main cause of acute toxicity in animals and humans.
Manupat Lohitnavy +4 more
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Physiological-based pharmacokinetic modeling of endotoxin in the rat
Toxicology and Industrial Health, 2012We have previously measured the distribution and pharmacokinetics of biosynthetically radiolabeled endotoxin of Salmonella typhimurium following intraperitoneal (IP) dosing (200 μg/kg) in Sprague-Dawley rats. In our experiments, the fatty acid residues were labeled with 3 H and the ...
Joseph C, Hutter, Chung S, Kim
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Physiologically Based Pharmacokinetic Models in Developmental Toxicology
Risk Analysis, 1994The kinetics of disposition of drugs and environmental chemicals will be altered as a result of the rapid and pronounced anatomic and physiologic changes that occur during pregnancy. These include changes in maternal intestinal motility, pulmonary tidal volume and minute volume, cardiac output, and renal function as well as in maternal tissue and fluid
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Physiologically-based pharmacokinetic modeling of pyrene in the rat
Environmental Toxicology and Pharmacology, 1998The objective of the present study was to develop a physiologically-based model to simulate the oral and i.v. pharmacokinetics of pyrene in the rat. The physiologically-based pharmacokinetic (PBPK) model for pyrene consisted of the following tissue compartments: liver, lungs, adipose tissue, slowly perfused tissues, and richly perfused tissues ...
S, Haddad +4 more
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Physiologically based pharmacokinetic model for vinylidene chloride
Toxicology and Applied Pharmacology, 1988Vinylidene chloride (VDC), a potent hepatotoxin and suspected carcinogen, is metabolized by mixed-function oxidases into a reactive metabolite(s) which is responsible for its toxicity. The metabolite is detoxified by glutathione (GSH), and liver GSH status is an important factor in the expression of VDC toxicity. A physiologically based pharmacokinetic
R W, D'Souza, M E, Andersen
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A Physiologically Based Pharmacokinetic Model of Inorganic Arsenic
Regulatory Toxicology and Pharmacology, 1999This study presents a physiologically based pharmacokinetic model of inorganic arsenic disposition in humans. The model focuses on short-term exposures by the oral route. The model considers the four circulating species (AsIII, AsV, and two metabolites, i.e., monomethylarsenic (MMA) and dimethylarsenic (DMA)) in tissue groups.
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Physiologically based pharmacokinetic modelling of cefoperazone in paediatrics
British Journal of Clinical PharmacologyAimsCefoperazone is commonly used off‐label in the treatment of bacterial meningitis and sepsis in children, and the pharmacokinetic (PK) data are limited in this vulnerable population. The goal of this study was to develop a physiologically based pharmacokinetic (PBPK) model to predict pediatric cefoperazone exposure for rational dosing ...
Qiushi Wang +4 more
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Physiologically based pharmacokinetic modeling
2007Deon van der Merwe +2 more
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