Results 51 to 60 of about 31,417,423 (292)

A Physiologically-Based Pharmacokinetic Model for Vancomycin [PDF]

, 2015
Vancomycin is an antibiotic used for the treatment of systemic infections. It is given intravenously usually every twelve or twenty-four hours. This particular drug has a medium level of boundedness, with approximately fty percent of the drug being free ...
White, Rebekah
core   +1 more source

Towards a Generic Tool for Prediction of Meropenem Systemic and Infection-Site Exposure: A Physiologically Based Pharmacokinetic Model for Adult Patients with Pneumonia

Drugs in R&D, 2019
Objective The objective of this study was to develop a physiologically based pharmacokinetic model for meropenem using a retrograde approach, which could serve as a basis for prediction of the systemic and infection-site drug exposures in different ...
Pauline Thémans, Pierre Marquet, Joseph J. Winkin, Flora T. Musuamba   +3 more
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Organoids as a Revolutionary Data Source for Pharmacokinetic Modeling: A Comprehensive Review

Future Pharmacology
The progress of contemporary pharmacology is deeply linked to pharmacokinetics (PK) and its quantitative exploration through PK modeling. By offering a robust mathematical framework to describe and predict drug absorption, distribution, metabolism, and ...
Lara Marques, Nuno Vale
doaj   +1 more source

Revisiting Cerebrospinal Fluid Flow Direction and Rate in Physiologically Based Pharmacokinetic Model

Pharmaceutics, 2022
The bidirectional pulsatile movement of cerebrospinal fluid (CSF), instead of the traditionally believed unidirectional and constant CSF circulation, has been demonstrated.
Makoto Hirasawa, Elizabeth C. M. de Lange   +1 more
doaj   +1 more source

Dimethyl Fumarate, But Not Rituximab, Reduces Serum GFAP Levels and PIRMA in Relapsing–Remitting MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Serum neurofilament light chain (sNfL) and glial fibrillary acidic protein (sGFAP) levels are believed to reflect mainly acute and chronic disease processes in multiple sclerosis (MS), respectively. In this study, we investigated whether dimethyl fumarate (DMF) and rituximab (RTX) differentially affect these biomarkers.
F. Shawket, J. Lycke, J. Salzer, F. Piehl, K. Fink, N. Lange, J. Mellergård, C. Malmeström, P. Sundström, I. Erngren, A. al‐Grety, E. Freyhult, K. Kultima, J. Burman, A. Svenningsson   +14 more
wiley   +1 more source

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Structure of pregnancy physiologically based pharmacokinetic (p-PBPK) model.

, 2015
Structure of pregnancy physiologically based pharmacokinetic (p-PBPK) model.
Saeed Alqahtani (802779), Amal Kaddoumi (802780)   +1 more
core   +1 more source

Predicting drug–drug interactions and optimal dosing of betrixaban with physiologically based pharmacokinetic modeling in patients with renal impairment who were coadministered with P-glycoprotein inhibitors

Journal of International Medical Research
Objective To optimize dosing adjustments in patients with renal impairment who were coadministered with P-glycoprotein inhibitors—verapamil or amiodarone—using a physiologically based pharmacokinetic model.
Xiaoping Yan, Lirong Xiao, Weina Xie
doaj   +1 more source

Prediction of pyrotinib exposure based on physiologically-based pharmacokinetic model and endogenous biomarker

Frontiers in Pharmacology, 2022
Pyrotinib, a novel irreversible epidermal growth factor receptor dual tyrosine kinase inhibitor, is mainly (about 90%) eliminated through cytochrome P450 (CYP) 3A mediated metabolism in vivo.
Miao Zhang, Miao Zhang, Miao Zhang, Zhiheng Yu, Zhiheng Yu, Zhiheng Yu, Xueting Yao, Xueting Yao, Zihan Lei, Zihan Lei, Zihan Lei, Kaijing Zhao, Wenqian Wang, Xue Zhang, Xijing Chen, Dongyang Liu, Dongyang Liu   +16 more
doaj   +1 more source