Results 31 to 40 of about 23,818,397 (163)

Best Practices in the Development and Validation of Physiologically Based Biopharmaceutics Modeling. A Workshop Summary Report

, 2022
S.584-593This workshop report summarizes the proceedings of Day 2 of a three-day workshop on ""Current State and Future Expectations of Translational Modeling Strategies to Support Drug Product Development, Manufacturing Changes and Controls"".
Wagner, C., Butler, J., Raines, K., Kakhi, M., Tsakalozou, E., Mullin, J., Pepin, X., Kesisoglou, F., Suarez-Sharp, S., Zhao, Y., Dressman, J., Flanagan, T., Pathak, S.M., Dallmann, A., Riedmaier, A.E., Patel, N., Parrott, N., Good, D., Li, M., Mitra, A.   +19 more
core   +1 more source

In Vitro Dissolution and in Silico Modeling Shortcuts in Bioequivalence Testing

Pharmaceutics, 2020
Purpose: To review in vitro testing and simulation platforms that are in current use to predict in vivo performances of generic products as well as other situations to provide evidence for biowaiver and support drug formulations development.
Moawia M. Al-Tabakha, Muaed J. Alomar
doaj   +1 more source

Analysis of Time-Dependent Pharmacokinetics Using In Vitro–In Vivo Extrapolation and Physiologically Based Pharmacokinetic Modeling

, 2022
SCR430, a sorafenib derivative, is an investigational drug exhibiting anti-tumor action. This study aimed to have a mechanistic understanding of SCR430’s time-dependent pharmacokinetics (TDPK) through an ex vivo study combined with an in vitro ...
Kim, Min-Chang, Young-Joo Lee, Min-Chang Kim, Lee, Young-Joo   +3 more
core   +1 more source

Dual Role of Tamoxifen in Enhancing STING and CEACAM1 Expression to Prime a Favorable Tumor Microenvironment for Anti‐TIM3 Immunotherapy

Advanced Science, EarlyView.
Anti‐PD‐1/PD‐L1 blockade has revolutionized cancer immunotherapy, but is ineffective against endocrine‐treated (i.e., Tamoxifen), relapsed ER+ breast cancer (BC) patients. This study provides insight into the sub‐optimal response of ER+BCs to anti‐PD‐1/PD‐L1 blockade – highlighting the induction of STING and the CEACAM1/TIM3 axis after chronic ...
Marvin Angelo E Aberin, Saurabh Singh, Soumya Chatterjee, Guang‐Zhi Sui, Yi‐Fu Wang, Ya‐Ting Lu, Yu‐Ling Lee, Kun‐Yuan Lin, Joy Khag, Ta‐Yu Liu, Shao‐Han Chang, Wai‐Mui Cheung, Hsiao‐Chin Hong, Ren‐Jun Hsu, Chen‐Yang Shen, Chia‐Wei Li, Weng‐Lang Yang, Yao‐Ming Chang, Shih‐Yu Chen, Chandan Guha, Shu‐Ping Wang   +20 more
wiley   +1 more source

Six years of progress in the oral biopharmaceutics area - A summary from the IMI OrBiTo project

, 2020
OrBiTo was a precompetitive collaboration focused on the development of the next generation of Oral Biopharmaceutics Tools. The consortium included world leading scientists from nine universities, one regulatory agency, one non-profit research ...
Augustijns, P.,, Lennernas, H., Abrahamsson, B., Müllertz, A., Holm, R.,, Langguth, P., Berntsson, M., Sjögren, Erik,, Muellertz, A.,, Berntsson, M.,, Pepin, X.,, Langguth, P.,, Muellertz, A., Butler, J.,, Butler, J., Lennernäs, Hans,, Augustijns, P., Rostami-Hodjegan, A.,, Pepin, X., Lindahl, A.,, Zane, P., Lindahl, A., Holm, R., McAllister, M., Rostami-Hodjegan, A., Abrahamsson, B.,, Sjogren, E., McAllister, M.,, Zane, P.,   +28 more
core   +1 more source

Parameterization of Physiologically Based Biopharmaceutics Models : Workshop Summary Report

This Article shares the proceedings from the August 29th, 2023 (day 1) workshop "Physiologically Based Biopharmaceutics Modeling (PBBM) Best Practices for Drug Product Quality: Regulatory and Industry Perspectives".
Carducci, Tessa,, Fotaki, Nikoletta, Kijima, Shinichi, Seo, Paul, Gray, Elizabeth, Heimbach, Tycho, Delvadia, Poonam, Mitra, Amitava, McAllister, Mark, Lennernäs, Hans, Loebenberg, Raimar,, Kotzagiorgis, Evangelos, Tsakalozou, Eleftheria,, Chatterjee, Parnali,, Veerasingham, Shereeni,, Malamatari, Maria, Holte, Oyvind,, McAllister, Mark,, Song, Ivy,, Pepin, Xavier,, Wagner, Christian, Gray, Elizabeth,, Ren, Xiaojun,, Arora, Sumit, Heimbach, Tycho,, Mackie, Claire, Lennernäs, Hans,, Mackie, Claire,, Chen, Grace,, Cristofoletti, Rodrigo, Borges, Luiza,, Pepin, Xavier, Scherholz, Megerle,, Holte, Oyvind, Tannergren, Christer,, Malamatari, Maria,, Lindahl, Anders, Tsakalozou, Eleftheria, Mudie, Deanna, Song, Ivy, Cano-Vega, Mario, Dallmann, Andre, Tannergren, Christer, Fotaki, Nikoletta,, Loebenberg, Raimar, Dressman, Jennifer,, Mitra, Amitava,, Moody, Rebecca,, Seo, Paul,, Wagner, Christian,, Chen, Grace, Scherholz, Megerle, Tshinanu, Flora Musuamba, Veerasingham, Shereeni, Carducci, Tessa, Tshinanu, Flora Musuamba,, Cristofoletti, Rodrigo,, Arora, Sumit,, Moody, Rebecca, Suarez-Sharp, Sandra, Rege, Bhagwant, Delvadia, Poonam,, Ren, Xiaojun, Polli, James E.,, Rullo, Gregory,, Polli, James E., Rege, Bhagwant,, Chatterjee, Parnali, Lindahl, Anders,, Mudie, Deanna,, Suarez-Sharp, Sandra,, Dressman, Jennifer, Borges, Luiza, Cano-Vega, Mario,, Kijima, Shinichi,, Rullo, Gregory, Stillhart, Cordula, Dallmann, Andre,, Kotzagiorgis, Evangelos,, Stillhart, Cordula,   +79 more
core   +3 more sources

A Pentaradial and Bilateral Combined Photoreception System in the Sea Cucumber is Mediated by a Blue Light‐Sensitive R‐Opsin

Advanced Science, EarlyView.
The sea cucumber Holothuria leucospilota detects blue and adjacent wavelengths of light via an r‐opsin with a maximum absorption at 459 nm. In the oral tentacles, papillae, and tube feet, distinct light‐sensing structures with specialized morphologies are formed, constituting a unique pentaradial and bilateral combined photoreception system.
Jiasheng Huang, Chunhua Ren, Zhou Qin, Yimeng Cui, Bingbing Zhang, Peng Luo, Xuan Wang, Yaoqi Xie, Xin Zhang, Aifen Yan, Yang Zhang, Dingding Fan, Yang Liu, Wenjie Pan, Xiao Jiang, Lihong Yuan, Haipeng Qin, David M. Irwin, Chaoqun Hu, Yang Liu, Ting Chen   +20 more
wiley   +1 more source

Lactiplantibacillus Plantarum GUANKE Alleviates Allergic Asthma by Restricting Monocyte‐to‐DC Differentiation Via Microbiota‐Associated IAA

Advanced Science, EarlyView.
Lactiplantibacillus plantarum GUANKE remodels the indigenous gut microbiota and is associated with microbiota‐dependent restoration of circulating IAA. IAA treatment attenuates JAK3‐STAT3 and Jag1‐Notch4‐Hey1 signaling and reduces CX3CR1+Ly6C− monocytic precursor generation and pulmonary CD11b+ DC accumulation, together with reduced Th2 inflammation ...
Yujia He, Jielan Mi, Zhiping Zhao, Xiao Zhang, Zhihan Yang, Kun Yue, Yuanming Huang, Liqiong Song, Xiaoting Wen, Jianguo Xu, Zhihong Ren   +10 more
wiley   +1 more source

Comparing Multi-Label Classification Methods for Provisional Biopharmaceutics Class Prediction. [PDF]

, 2014
The biopharmaceutical classification system (BCS) is now well established and utilized for the development and biowaivers of immediate oral dosage forms. The prediction of BCS class can be carried out using multilabel classification.
Taravat Ghafourian, Ghafourian, Taravat, Danielle Newby (1695076), Newby, D., Danielle Newby, Taravat Ghafourian (4466557), Alex Freitas (3762685), Freitas, Alex A., Alex. A. Freitas   +8 more
core   +1 more source

Self‐Assembling Peptide‐Adjuvant Conjugate (SaPAC) Platform for Precision Cancer Immunotherapy

Advanced Science, EarlyView.
A self‐assembling peptide–adjuvant conjugate links neoantigens to TLR7 agonism, forming cationic nanoparticles that enhance lymph‐node retention, dendritic‐cell activation, and antitumor T‐cell immunity. This chemically defined platform shows how synchronized antigen and innate stimulation can be adapted across melanoma, bladder cancer, and triple ...
Yang‐Fan Wu, Jing‐Chu Hu, Ye‐Fan Hu, Wen‐Jun Li, Li Rong, Ren‐Hao Li, Yuan Yao, Lehan Hu, Xiao‐Lei Wang, Bao‐Zhong Zhang, Yicheng Lu, Shing‐Fung Chow, Canhui Su, Thomas Yau, Clive Yik‐Sham Chung, Jian‐Dong Huang   +15 more
wiley   +1 more source