Results 31 to 40 of about 2,897 (211)

Simulated rat intestinal fluid improves oral exposure prediction for poorly soluble compounds over a wide dose range [PDF]

, 2016
Solubility can be the absorption limiting factor for drug candidates and is therefore a very important input parameter for oral exposure prediction of compounds with limited solubility.
Bernard Faller, Frank H. Seiler, Jörg Berghausen, Nathalie Gobeau   +3 more
core   +7 more sources

Understanding effect site pharmacology of uprifosbuvir, a hepatitis C virus nucleoside inhibitor: Case study of a multidisciplinary modeling approach in drug development

CPT: Pharmacometrics & Systems Pharmacology, 2021
Uprifosbuvir is a uridine nucleoside monophosphate prodrug inhibitor of the hepatitis C virus NS5B RNA polymerase. To quantitatively elucidate key metabolic pathways, assess the link between unmeasurable effect site concentrations and viral load ...
Paul van den Berg, Wei Gao, Maurice J. Ahsman, Leticia Arrington, Filippos Kesisoglou, Randy Miller, Teun M. Post, Matthew L. Rizk   +7 more
doaj   +1 more source

Population variability in animal health: Influence on dose-exposure-response relationships: Part II: Modelling and simulation [PDF]

, 2018
During the 2017 Biennial meeting, the American Academy of Veterinary Pharmacology and Therapeutics hosted a 1‐day session on the influence of population variability on dose‐exposure‐response relationships. In Part I, we highlighted some of the sources of
Bailey, Bon, Cox, Darwich, Dorey, Duwal, Ette, Fink, Jamei, Jamei, Jeunesse, Li, Li, Lin, Maaland, Margolskee, Margolskee, Martinez, Martinez, Martinez, Mochel, Mochel, Mochel, Mochel, Mochel, Mould, Ogungbenro, Pade, Pade, Paulson, Pelligand, Rey, Rostami-Hodjegan, Sheiner, Silber, Sjögren, Toutain, Tsamandouras, T’jollyn, Willmann, Zhuang   +40 more
core   +4 more sources

Integrating In Vitro Biopharmaceutics into Physiologically Based Biopharmaceutic Model (PBBM) to Predict Food Effect of BCS IV Zwitterionic Drug (GSK3640254)

Pharmaceutics, 2023
A strategy followed to integrate in vitro solubility and permeability data into a PBBM model to predict the food effect of a BCS IV zwitterionic drug (GSK3640254) observed in clinical studies is described. The PBBM model was developed, qualified and verified using clinical data of an immediate release (IR)-tablet (10–320 mg) obtained in healthy ...
Konstantinos Stamatopoulos, Paola Ferrini, Dung Nguyen, Ying Zhang, James M. Butler, Jon Hall, Nena Mistry   +6 more
openaire   +3 more sources

Comparison of Compartmental and Non-Compartmental Analysis to Detect Biopharmaceutical Similarity of Intravenous Nanomaterial-Based Rifabutin Formulations

Pharmaceutics, 2023
Pharmacometric analysis is often used to quantify the differences and similarities between formulation prototypes. In the regulatory framework, it plays a significant role in the evaluation of bioequivalence.
Nadezhda Osipova, Andrey Budko, Olga Maksimenko, Elena Shipulo, Ludmila Vanchugova, Wenqian Chen, Svetlana Gelperina, Matthias G. Wacker   +7 more
doaj   +1 more source

Physiology-based IVIVE predictions of tramadol from in vitro metabolism data [PDF]

, 2014
To predict the tramadol in vivo pharmacokinetics in adults by using in vitro metabolism data and an in vitro-in vivo extrapolation (IVIVE)-linked physiologically-based pharmacokinetic (PBPK) modeling and simulation approach (SimcypA (R)).
Allegaert, Karel, Annaert, Pieter, Boussery, Koen, Colin, Pieter, Cuyckens, Filip, Mannens, Geert, Snoeys, Jan, T'jollyn, Huybrecht, Van Bocxlaer, Jan, Van Peer, Achiel, Vermeulen, An   +10 more
core   +1 more source

Development of Biopredictive Dissolution Method for Extended-Release Desvenlafaxine Tablets

Pharmaceutics, 2023
This study aimed to develop a biopredictive dissolution method for desvenlafaxine ER tablets using design of experiments (DoE) and physiologically based biopharmaceutics modeling (PBBM) to address the challenge of developing generic drug products by ...
Gustavo Vaiano Carapeto, Marcelo Dutra Duque, Michele Georges Issa, Humberto Gomes Ferraz   +3 more
doaj   +1 more source

The Role of Transporters in the Pharmacokinetics of Orally Administered Drugs [PDF]

, 2009
Drug transporters are recognized as key players in the processes of drug absorption, distribution, metabolism, and elimination. The localization of uptake and efflux transporters in organs responsible for drug biotransformation and excretion gives ...
Sarah Shugarts, Leslie Z. Benet, RL Juliano, MF Fromm, CP Landowski, N Mizuno, CY Wu, GL Amidon, C Srimaroeng, ZM Zaïr, G Ciarimboli, B Hagenbuch, Y Toyoda, SF Zhou, H Kusuhara, S Choudhuri, BL Urquhart, AD Mottino, LW Chinn, K Maeda, T Nakamura, JE Montfoort van, M Okabe, L Li, LM Satlin, C Mahagita, A Kosters, T Takagi, NA Kasim, Y Yang, LZ Benet, H Lennernäs, N Li, M Katoh, X Cao, R Hayeshi, JM Arthur, D Sun, ML Chen, Y Shirasaka, U Fagerholm, CY Wu, X Cao, CL Cummins, CL Cummins, UI Schwarz, K Westphal, JS Lee, AL Sesink, Y Su, H Glaeser, Y Koitabashi, A Dahan, B Greiner, JM Custodio, RG Tirona, Y Su, T Watanabe, YY Lau, HX Zheng, JW Deng, Y Shu, X Tian, N Zelcer, RB Parker, LZ Benet, GA Kullak-Ublick, C Solas, S Zhou, SX Peng, C Tannergren, S Sahin, Y Kato, C Luna- Tortós, K Engel, M Zhou, BL Urquhart, MO Magnusson, N Ishiguro, Q Wang, DG Bailey, SR Vavricka, U Muenster, K Takenaka, DA Volpe, C Hilgendorf, M Lohitnavy, T Lavé, SS Buck De, Z Wang, N Parrott, A Bonen, M Grube, W Lee, MJ Bijvelds, JH Gray, RP Owen, A Bodo, Q Tian, L Ci, RD Huber, B Gao, G Jedlitschky, M Farias, SY Yao, D Kirat, D Meredith, I Knutter, DA Groneberg, M Hayer-Zillgen, S Sakamoto, H Li, JY Li, H Yabuuchi, I Elimrani, ILMH Aye, JD Allen, O Janneh, K Fujiwara, H Potschka, E Pollex, F Boraldi, W Lin, KR Robillard, AJ Smith, M Hirano, E Jigorel, EM Leslie, RB Kim, S Khamdung, S Halwachs, A Geick, O Burk, HR Kast, J Staudinger, M Assem, I Szatmari, M Ananthanarayanan, JJ Eloranta, Y Miki, JM Maglich, D Jung, Y Morita, S Hoffmeyer, Y Kurata, SY Yi, FA Jong de, A Sparreboom, A Sparreboom, W Zhang, Y Nishizato, J Mwinyi, M Niemi, M Niemi, I Ieiri, MK Pasanen, W Zhang, DA Katz, X Xiang, S Oswald, SV Vormfelde, M Miura   +161 more
core   +3 more sources

Physiologically based modeling and prediction of drug interactions [PDF]

, 2010
International audienceA major challenge for drug development and environmental or occupational health is the prediction of pharmacokinetic and pharmacodynamic interactions between drugs, natural chemicals or environmental contaminants.
Bois, Frédéric Y.
core   +3 more sources

SubQ-Sim: A Subcutaneous Physiologically Based Biopharmaceutics Model. Part 1: The Injection and System Parameters

Pharmaceutical Research, 2023
AbstractPurposeTo construct a detailed mechanistic and physiologically based biopharmaceutics model capable of predicting 1) device-formulation-tissue interaction during the injection process and 2) binding, degradation, local distribution, diffusion, and drug absorption, following subcutaneous injection.
Xavier J. H. Pepin, Iain Grant, J. Matthew Wood   +2 more
openaire   +2 more sources