Results 41 to 50 of about 2,897 (211)
Food and bile micelle binding of quaternary ammonium compounds
ADMET and DMPK, 2023 Background and Purpose: Physiologically-based biopharmaceutics modeling (PBBM) has been widely used to predict the oral absorption of drugs. However, the prediction of food effects on oral drug absorption is still challenging, especially for negative ...
Sumiji Takeru, Kiyohiko Sugano
doaj +1 more source
Journal of Pharmacy and Pharmacology, 2016 AbstractObjectivesThe aim of this study was (1) to determine how closely physiologically based pharmacokinetic (PBPK) models can predict oral bioavailability using a priori knowledge of drug-specific properties and (2) to examine the influence of the biopharmaceutics classification system class on the simulation success.MethodsSimcyp Simulator ...
Hansmann +5 more
openaire +3 more sources
Interaction of Rifampin and Darunavir-Ritonavir or Darunavir-Cobicistat In Vitro [PDF]
, 2017 Treatment of HIV-infected patients coinfected with Mycobacterium tuberculosis is challenging due to drug-drug interactions (DDIs) between antiretrovirals (ARVs) and antituberculosis (anti-TB) drugs.
Khoo, Saye +3 more
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Pharmaceutics, 2020 In the present work, we explored if Coca-Cola® had a beneficial impact on the systemic outcome of the weakly basic drug loratadine (Wal-itin®, immediate-release formulation, 10 mg, generic drug product).
Bart Hens +5 more
doaj +1 more source
The Use of ROC Analysis for the Qualitative Prediction of Human Oral Bioavailability from Animal Data [PDF]
, 2013 PURPOSE: To develop and evaluate a tool for the qualitative prediction of human oral bioavailability (F(human)) from animal oral bioavailability (F(animal)) data employing ROC analysis and to identify the optimal thresholds for such predictions. METHODS:
Aleksandra Galetin +5 more
core +1 more source
Estimating metabolic rate for butadiene at steady state using a Bayesian physiologically-based pharmacokinetic model [PDF]
, 2011 In a study of 133 volunteer subjects, demographic, physiologic and pharmacokinetic data through exposure to 1,3-Butadiene (BD) were collected in order to estimate the percentage of BD concentration metabolized at steady state, and to determine whether
Bois, FY +4 more
core +4 more sources
Developmental toxicity of combined ethylbenzene and methylethylketone administered by inhalation to rats [PDF]
, 2006 Pregnant Sprague–Dawley rats were exposed to ethylbenzene (EB; 0, 250, or 1000 ppm) and methylethylketone (MEK; 0, 1000, or 3000 ppm), alone and in combination, by inhalation, for 6 h/day, during days 6–20 of gestation.
Bourges-Abella, Nathalie +6 more
core +1 more source
Molecular Pharmaceutics, 2023 The rate and extent of colon absorption are important determinants of the in vivo performance of extended-release (ER) drug products. The ability to appropriately predict this at different stages of development using mechanistic physiologically based biopharmaceutic modeling (PBBM) is highly desirable.
Jadhav, Harshad +2 more
openaire +2 more sources
In Vitro Dissolution and in Silico Modeling Shortcuts in Bioequivalence Testing
Pharmaceutics, 2020 Purpose: To review in vitro testing and simulation platforms that are in current use to predict in vivo performances of generic products as well as other situations to provide evidence for biowaiver and support drug formulations development.
Moawia M. Al-Tabakha, Muaed J. Alomar
doaj +1 more source
Parameterization of Physiologically Based Biopharmaceutics Models: Workshop Summary Report
Molecular PharmaceuticsThis Article shares the proceedings from the August 29th, 2023 (day 1) workshop "Physiologically Based Biopharmaceutics Modeling (PBBM) Best Practices for Drug Product Quality: Regulatory and Industry Perspectives". The focus of the day was on model parametrization; regulatory authorities from Canada, the USA, Sweden, Belgium, and Norway presented ...
Xavier Pepin +39 more
openaire +3 more sources