Results 131 to 140 of about 20,264 (293)

Physiologically Based Pharmacokinetic Modeling and Dose Optimization of Linezolid in Pediatric Patients With Renal Impairment

Drug Design, Development and Therapy
Jia-Qi Lou,1 Ben-Nian Huo,1 Ya Yang,1 Shu-Feng Wang,2 Lu-Dan Zhang,1 Yun-Tao Jia,1 Lin Song1 1Department of Pharmacy, Children’s Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of ...
Lou JQ, Huo BN, Yang Y, Wang SF, Zhang LD, Jia YT, Song L   +6 more
doaj  

A Synergistic Hydrogel‐Microalgae Platform for Dual‐Targeting of Intestinal and Neuroimmune Dysfunction in Inflammatory Bowel Disease

Advanced Science, EarlyView.
A bioactive hydrogel incorporating Chlorella vulgaris and paeoniflorin within a carboxymethyl chitosan/sodium alginate matrix cross‐linked with genipin is developed for inflammatory bowel disease therapy. The hydrogel exhibits gastric stability and intestine‐responsive release.
Jing Lu, Kangyu Jin, Bing Chen, Ruoxi Wang, Fengling Hu, Shaohua Hu, Danni Zhong, Xiaoming Li, Min Zhou   +8 more
wiley   +1 more source

[A physiologically-based pharmacokinetic model for 2,3,7,8-TCDD in the cow.]

, 2012
niet beschikbaarIn this report the development of a physiologically-based pharmacokinetic model for 2,3,7,8-TCDD in cows is presented. The following aspects are successively dealt with: - design of the model structure - collection and justification of ...
Jong APJM de, Everts H, Olling M, Berende PLM, Derks HJGM, Liem AKD   +5 more
core  

ESCRT‐Mimetic Nanodegrader Targets STING for Anti‐Inflammatory Therapy

Advanced Science, EarlyView.
A nanoplatform‐enabled targeted protein degradation strategy is presented to regulate aberrant STING signaling. STING‐ATTEC induces selective autophagic degradation of STING via formation of a STING–ATTEC–LC3 ternary complex, while the cationic FA‐LNP+ system enhances LC3 generation and targeted delivery. Together, this synergistic approach efficiently
Fuyuan Zhou, Qiming Zhai, Zhihao Yao, Qing Li, Yan Yang, Si Wang, Chao Huang, Liangjing Xin, Tao Chen, Jinlin Song   +9 more
wiley   +1 more source

PRT to predict pharmacokinetic profiles as part of a bioequivalence study of the drug deferasirox

Разработка и регистрация лекарственных средств
Introduction. Deferasirox is a complexing drug and belongs to class II according to the biopharmaceutical classification system (BCS), has acidic properties and belongs to subclass “a” (acid).
A. V. Suvorova, P. A. Losenkova, Yu. V. Medvedev, E. A. Malashenko, I. E. Makarenko, A. M. Poluyanov, I. E. Shohin   +6 more
doaj   +1 more source

Physiologically-Based Pharmacokinetic Modeling for Predicting Drug-Drug Interactions

, 2011
Dynamics of interactions between the drugs caffeine and ciprofloxacin are predicted using physiologically-based pharmacokinetic (PBPK) modeling.
Ng, David M., Navid, Ali
core  

Nanozymes for Advanced Hemoglobin‐Based Oxygen Carriers: Applications in Blood Substitution, Wound Healing, Antitumor Therapy, and Beyond

Advanced Science, EarlyView.
This review explores how hemoglobin‐based oxygen carriers (HBOCs) combined with nanozymes create multifunctional materials that deliver oxygen while maintaining redox homeostasis. Beyond artificial blood substitutes, these constructs enable wound healing with light‐triggered oxygen release, cancer therapy through enhanced oxygenation and reactive ...
Despoina Douka, Ana María Pablo‐Sainz‐Ezquerra, Eva Jakljevič, Niki Ktena, Leticia Hosta‐Rigau   +4 more
wiley   +1 more source

The Effect of Liver and Kidney Disease on the Pharmacokinetics of Clozapine and Sildenafil: A Physiologically Based Pharmacokinetic Modeling

Drug Design, Development and Therapy, 2020
Amira M Ghoneim,1 Suzan M Mansour2,3 1Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmaceutical Sciences and Pharmaceutical Industries, Future University in Egypt, Cairo, Egypt; 2Pharmacology & Toxicology Department ...
Ghoneim AM, Mansour SM
doaj  

Physiologically-based pharmacokinetic modeling for predicting caffeine/theophylline-ciprofloxacin interactions

, 2013
Dynamics of interactions between the drugs caffeine, theophylline, and ciprofloxacin are predicted using physiologically-based pharmacokinetic (PBPK) modeling.
Ng, David M., Navid, Ali
core  

Statistical Analysis based on Physiologically-based Pharmacokinetic Models

, 2009
Physiologically-based pharmacokinetic (PBPK) modeling has reached considerable sophistication in its application in the pharmacological and environmental health areas.
Klein, Martin D.
core   +1 more source