Results 221 to 230 of about 20,264 (293)

AND‐Logic‐Gated Aptamer Switch for Precise Targeting and Regulation of RNA G‐Quadruplexes

Angewandte Chemie, EarlyView.
An AND‐logic‐gated aptamer switch enables tumor‐selective activation of RNA G‐quadruplex (rG4)‐targeting function. By combining cell‐surface recognition and intracellular redox sensing, the system achieves precise regulation of disease‐relevant RNA structures exclusively in tumor cells, with minimal off‐target effects in normal cells, offering a ...
Dan Wang, Ying Feng, Chun Kit Kwok
wiley   +2 more sources

A physiologically based pharmacokinetic model of diethyl phthalates in humans. [PDF]

Environ Pollut
Chen S, Shi Z, Zhang Q.
europepmc   +1 more source

Therapeutic Applications of Stimuli‐Based Release and Engineering of Extracellular Vesicles

Advanced NanoBiomed Research, EarlyView.
This review summarizes the effects of endogenous and exogenous stimuli, their effects on the natural release of extracellular vesicles, as well as their uptake and release. It also gives an overview of stimuli‐responsive EVs and their therapeutic applications. Extracellular vesicles (EVs), nano‐ to microsized lipid bilayer membrane‐bound particles, are
Gloria Kemunto, Kristen Dellinger
wiley   +1 more source

Development of Sub‐50 nm Core–Shell Silica Nanoparticles With Controlled In Vivo Behavior for 19F Magnetic Resonance Imaging

Angewandte Chemie, EarlyView.
Ultrasmall PFCE‐loaded silica nanoparticles synthesized through a one‐pot double‐emulsion synthesis method, where rapid silica shell formation kinetically fixes droplet size. The resulting s‐FLAME nanoparticles enable strong 19F MRI signals with enhanced hepatic clearance rate and tumor‐accumulation performance. ABSTRACT 19F magnetic resonance imaging (
Yue Wu, Masafumi Minoshima, Kazuya Kikuchi   +2 more
wiley   +2 more sources

Physiologically-based pharmacokinetic model for CAR-T cells delivery and efficacy in solid tumors

Hadjigeorgiou AG, Munn LL, Stylianopoulos T, Jain RK.   +3 more
europepmc   +1 more source

Prediction of SPT-07A Pharmacokinetics in Rats, Dogs, and Humans Using a Physiologically-Based Pharmacokinetic Model and In Vitro Data. [PDF]

Pharmaceutics
Zhu X, Kong W, Wang Z, Liu X, Liu L.
europepmc   +1 more source

Liposomal Delivery of L‐2‐Hydroxyglutarate for Targeting Epigenetic Dysregulation in Osteoarthritis

Advanced NanoBiomed Research, EarlyView.
Osteoarthritis involves cartilage degeneration, inflammation, and epigenetic dysregulation. A liposomal formulation of the TET1 inhibitor L‐2‐hydroxyglutarate to overcome rapid joint clearance was developed. The formulation showed good physicochemical properties, reduced inflammatory and catabolic gene expression in chondrocytes, and alleviated ...
Denise Murgia, Akshay Pandey, Raffaele Spanò, Bianca Martins Estevão, Roberto Palomba, Greta Avancini, Tamaghna Gupta, Ana Maria Lopez Estevez, Stuart B. Goodman, Nidhi Bhutani, Paolo Decuzzi   +10 more
wiley   +1 more source

Development of a physiologically-based pharmacokinetic model for Ritonavir characterizing exposure and drug interaction potential at both acute and steady-state conditions. [PDF]

CPT Pharmacometrics Syst Pharmacol
Ngo LT, Jung W, Bui TT, Yun HY, Chae JW, Momper JD.   +5 more
europepmc   +1 more source

Whole Body Physiologically Based Pharmacokinetic Model to Explain A Patient With Drug-Drug Interaction Between Voriconazole and Flucloxacillin. [PDF]

Eur J Drug Metab Pharmacokinet
Abdullah-Koolmees H, van den Nieuwendijk JF, Hoope SMKT, de Leeuw DC, Franken LGW, Said MM, Seefat MR, Swart EL, Hendrikse NH, Bartelink IH.   +9 more
europepmc   +1 more source

Development of a physiologically-based pharmacokinetic model to simulate the pharmacokinetics of intramuscular antiretroviral drugs. [PDF]

CPT Pharmacometrics Syst Pharmacol
Bettonte S, Berton M, Battegay M, Stader F, Marzolini C.   +4 more
europepmc   +1 more source