Results 71 to 80 of about 23,888,926 (291)
Advanced Healthcare Materials, EarlyView.In this study, Hammer et al. highlight cyclic‐arginine surface engineering as a highly biocompatible, controllable, and concentration‐dependent regulator of intravitreal nanoparticle mobility in vivo in a translational large animal model. The cyclic arginine surface‐modification supports the development of next‐generation biomaterials for long‐acting ...
Maximilian Hammer +12 more
wiley +1 more source
A Comprehensive Framework for Physiologically‐Based Pharmacokinetic Modeling in Matlab
CPT: Pharmacometrics & Systems Pharmacology, 2019 Physiologically‐based pharmacokinetic (PBPK) models are useful tools to predict clinical scenarios for special populations for whom there are high hurdles to conduct clinical trials such as children or the elderly.
Felix Stader +3 more
doaj +1 more source
Clinical and Translational Science, 2021 Sjögren’s syndrome (SS) is an autoimmune disease with no effective treatment options. Resolvin D1 (RvD1) belongs to a class of lipid‐based specialized pro‐resolving mediators that showed efficacy in preclinical models of SS.
Venkata K. Yellepeddi +5 more
doaj +1 more source
Physiologically-Based Pharmacokinetic Modeling for Predicting Drug-Drug Interactions [PDF]
, 2011 Dynamics of interactions between the drugs caffeine and ciprofloxacin are predicted using physiologically-based pharmacokinetic (PBPK) modeling.
Ng, David M., Navid, Ali
core
Advanced Healthcare Materials, EarlyView.Biologically derived and hybrid nonviral nanovectors are examined as distinct but convergent design approaches. Integrating synthetic components with biologically functionalized membranes allows efficient interactions with complex cellular environments.
Clara Baldari +10 more
wiley +1 more source
Physiologically Based Pharmacokinetic Modeling and Simulation in Pediatric Drug Development
CPT: Pharmacometrics & Systems Pharmacology, 2014 Increased regulatory demands for pediatric drug development research have fostered interest in the use of modeling and simulation among industry and academia.
A R Maharaj, A N Edginton
doaj +1 more source
Drug Dosing in Pregnant Women: Challenges and Opportunities in Using Physiologically Based Pharmacokinetic Modeling and Simulations. [PDF]
, 2018 Contains fulltext : 191232.pdf (Publisher’s version ) (Open Access)The unmet medical need of providing evidence-based pharmacotherapy for pregnant women is recognized by the regulatory bodies. Physiologically based pharmacokinetic (PBPK)
Ke, A.B., Greupink, R., Abduljalil, K.
core +2 more sources
Advanced Healthcare Materials, EarlyView.FeS‐VA@lanifibranor (FVL), an activated hepatic stellate cell (aHSC)‐targeted nanoplatform comprising vitamin A‐functionalized two‐dimensional iron sulfide nanosheets and lanifibranor, is engineered for precision therapy of liver fibrosis. FVL suppresses the TGF‐β signaling pathway by inhibiting SMAD2/3 phosphorylation and induces ferroptosis in aHSCs,
Yinuo Yang +11 more
wiley +1 more source
Advanced Healthcare Materials, EarlyView.A folic acid (FA)‐conjugated 2‐deoxyglucose dendrimer selectively targets FRβ+ macrophages in endometriotic lesions, enabling precise intracellular delivery of niclosamide. This nonhormonal nanomedicine enhances drug solubility, provides controlled intracellular release, suppresses lesion growth, reduces inflammation and pain, and establishes FRβ ...
Anubhav Dhull +11 more
wiley +1 more source
A physiologically-based pharmacokinetic model for the antibiotic ertapenem
Mathematical Biosciences and Engineering, 2016 Ertapenem is an antibiotic commonly used to treat a broad spectrum of infections, which is part of a broader class of antibiotics called carbapenem. Unlike other carbapenems, ertapenem has a longer half-life and thus only has to be administered once a day.
Michele L. Joyner +4 more
openaire +5 more sources