Results 51 to 60 of about 23,888,926 (291)

Adapting Physiologically-Based Pharmacokinetic Models for Machine Learning Applications

, 2023
Materials (code, data files) associated with the paper ' Adapting Physiologically-Based Pharmacokinetic Models for Machine Learning Applications
Reisfeld, Brad, Habiballah, Sohaib
core   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Physiologically based pharmacokinetic modeling of PLGA nanoparticles with varied mPEG content

International Journal of Nanomedicine, 2012
Mingguang Li1, Zoi Panagi2, Konstantinos Avgoustakis2, Joshua Reineke11Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI, USA; 2Pharmaceutical Technology Laboratory ...
Avgoustakis K, Li M, Panagi Z, Reineke J
doaj  

Immunomodulatory Effects of Atractylodes lancea in Healthy Volunteers with Dosage Prediction for Cholangiocarcinoma Therapy: A Modelling Approach

Pharmaceuticals
Background and Aims: According to a recent study on the immunomodulatory activity of Atractylodes lancea (Thunb.) DC. (AL) in healthy Thai subjects, AL significantly inhibited the production of key pro-inflammatory cytokines while stimulating the ...
Teerachat Saeheng, Juntra Karbwang, Kesara Na-bangchang   +2 more
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Physiologically based pharmacokinetic (PBPK) model of chlorzoxazone

, 2023
This repository provides the chlorzoxazone physiologically based pharmacokinetic (PBPK) model. If you have any questions or problems please open an issue FundingMatthias König were supported by the Federal Ministry of Education and Research (BMBF ...
Küttner, Jonas, König, Matthias
core   +3 more sources

Dimethyl Fumarate, But Not Rituximab, Reduces Serum GFAP Levels and PIRMA in Relapsing–Remitting MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Serum neurofilament light chain (sNfL) and glial fibrillary acidic protein (sGFAP) levels are believed to reflect mainly acute and chronic disease processes in multiple sclerosis (MS), respectively. In this study, we investigated whether dimethyl fumarate (DMF) and rituximab (RTX) differentially affect these biomarkers.
F. Shawket, J. Lycke, J. Salzer, F. Piehl, K. Fink, N. Lange, J. Mellergård, C. Malmeström, P. Sundström, I. Erngren, A. al‐Grety, E. Freyhult, K. Kultima, J. Burman, A. Svenningsson   +14 more
wiley   +1 more source

A physiologically based pharmacokinetic model of vitamin D [PDF]

Journal of Applied Toxicology, 2017
AbstractDespite the plethora of studies discussing the benefits of vitamin D on physiological functioning, few mathematical models of vitamin D predict the response of the body on low‐concentration supplementation of vitamin D under sunlight‐restricted conditions.
Megan E. Sawyer, Hien T. Tran, Marina V. Evans   +2 more
openaire   +2 more sources

Physiologically-Based Pharmacokinetic Modeling of Acetaminophen Metabolism and Toxicity [PDF]

, 2012
Acetaminophen is a common analgesic and antipyretic. Metabolism of acetaminophen and acetaminophen-induced liver necrosis are predicted using physiologically-based pharmacokinetic (PBPK) modeling. Pharmacokinetic means the model determines where the drug
Ng, David M., Navid, Ali
core  

Bisphenol A-toxicity and risk assessment update with academic and regulatory perspectives and physiologically based pharmacokinetic modeling

, 2022
[[abstract]]The present review provides an update on new research activities and data available on the health effects evaluation and physiologically based pharmacokinetic (PBPK) modeling of BPA.
Fan, AM;Chou, WC;Lin, P
core   +1 more source