Results 31 to 40 of about 23,888,926 (291)

Quality Control Dissolution Data Is Biopredictive for a Modified Release Ropinirole Formulation: Virtual Experiment with the Use of Re-Developed and Verified PBPK Model

Pharmaceutics, 2022
Physiologically based pharmacokinetic and absorption modeling are being used by industry and regulatory bodies to address various scientifically challenging questions. While there is high confidence in the prediction of exposure for the BCS class I drugs
Olha Shuklinova, Przemysław Dorożyński, Piotr Kulinowski, Sebastian Polak   +3 more
doaj   +1 more source

ATLAS mPBPK: A MATLAB‐Based Tool for Modeling and Simulation of Minimal Physiologically‐Based Pharmacokinetic Models

CPT: Pharmacometrics & Systems Pharmacology, 2019
Minimal physiologically‐based pharmacokinetic (mPBPK) models are frequently used to model plasma pharmacokinetic (PK) data and utilize and yield physiologically relevant parameters. Compared with classical compartment and whole‐body physiologically‐based
Panteleimon D. Mavroudis, Vivaswath S. Ayyar, William J. Jusko   +2 more
doaj   +1 more source

A compatibility evaluation between the physiologically based pharmacokinetic (PBPK) model and the compartmental PK model using the lumping method with real cases

Frontiers in Pharmacology, 2022
Pharmacokinetic (PK) modeling is a useful method for investigating drug absorption, distribution, metabolism, and excretion. The most commonly used mathematical models in PK modeling are the compartment model and physiologically based pharmacokinetic ...
Hyo-jeong Ryu, Won-ho Kang, Taeheon Kim, Jae Kyoung Kim, Jae Kyoung Kim, Kwang-Hee Shin, Jung-woo Chae, Hwi-yeol Yun   +7 more
doaj   +1 more source

A Physiologically Based Pharmacokinetic Model of Rifampin in Mice [PDF]

Antimicrobial Agents and Chemotherapy, 2013
ABSTRACT One problem associated with regimen-based development of antituberculosis (anti-TB) drugs is the difficulty of a systematic and thorough in vivo evaluation of the large number of possible regimens that arise from consideration of multiple drugs tested together.
Michael A, Lyons, Brad, Reisfeld, Raymond S H, Yang, Anne J, Lenaerts   +3 more
openaire   +2 more sources

Bridging inhaled aerosol dosimetry to physiologically based pharmacokinetic modeling for toxicological assessment: nicotine delivery systems and beyond [PDF]

, 2019
One of the challenges for toxicological assessment of inhaled aerosols is to accurately predict their deposited and absorbed dose. Transport, evolution, and deposition of liquid aerosols are driven by complex processes dominated by convection-diffusion ...
Hoeng, J., Kolli, A.R., Martin, F., Peitsch, M.C., Hayes, A.W., Kuczaj, A.K.   +5 more
core   +2 more sources

Physiologically Based and Population Pharmacokinetic Modeling of Midazolam in Children With Obesity Using Real‐World Data [PDF]

Children represent a highly complex and variable population for treatment, including interindividual differences in drug dose–exposure. Midazolam has been used as a sedative for hospitalized children on‐ and off‐label; however, factors affecting ...
Stephen J. Balevic, Andrea N. Edginton, Victória E. Helfer, Sarah G. Anderson, Daniel Gonzalez, the Best Pharmaceuticals for Children Act Pediatric Trials Network Steering Committee, Amira Al‐Uzri, Sean McCann, Marisa L. Meyer, William J. Muller, John N. van denAnker, Sitora Turdalieva   +11 more
core   +3 more sources

Applications of PBPK Modeling to Estimate Drug Metabolism and Related ADME Processes in Specific Populations

Pharmaceutics
Background: Physiologically based pharmacokinetic (PBPK) models utilize computer-based simulations to predict the pharmacokinetics of drugs. By using mathematical modeling techniques consisting of differential equations to simulate blood flow, tissue ...
Pavani Gonnabathula, Miao Li, Suresh K. Nagumalli, Darshan Mehta, Kiara Fairman   +4 more
doaj   +1 more source

A physiologically based pharmacokinetic model for ionic silver and silver nanoparticles [PDF]

, 2013
Gerald Bachler, Natalie von Goetz, Konrad Hungerbühler ETH Zurich, Institute for Chemical and Bioengineering, Zurich, Switzerland Abstract: Silver is a strong antibiotic that is increasingly incorporated into consumer products as a bulk, salt, or ...
von Goetz, Natalie, Hungerbühler, Konrad, Bachler G, Hungerbühler K, Bachler, Gerald, von Goetz N   +5 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Whole-Body Physiologically Based Pharmacokinetic Modeling of GalNAc-Conjugated siRNAs

Pharmaceutics
Background/Objectives: N-acetyl-galactosamine small interfering RNAs (GalNAc-siRNA) are an emerging class of drugs due to their durable knockdown of disease-related proteins.
Emilie Langeskov Salim, Kim Kristensen, Erik Sjögren   +2 more
doaj   +1 more source