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Development of Physiologically Based Pharmacokinetic (PBPK) Modeling
PharmaceuticsIn this Special Issue, “Development of Physiologically Based Pharmacokinetic (PBPK) Modeling”, readers can find a selection of articles that discuss the most current challenges and advances in this area [...]
Bárbara Sánchez-Dengra +1 more
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Molecules, 2022 Natural medicine has been widely used for clinical treatment and health care in many countries and regions. Additionally, extracting active ingredients from traditional Chinese medicine and other natural plants, defining their chemical structure and ...
Qiuyu Jia +7 more
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Physiologically based pharmacokinetic (PBPK) modeling and simulation in drug discovery and development [PDF]
ADMET and DMPK, 2019 Physiologically based pharmacokinetic (PBPK) modeling is a mechanistic or physiology based mathematical modeling technique which integrates the knowledge from both drug-based properties including physiochemical and biopharmaceutical properties and system
Abdul Naveed Shaik, Ansar Ali Khan
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Physiologically Based Pharmacokinetic Modeling in Neonates: Current Status and Future Perspectives
Pharmaceutics, 2023 Rational drug use in special populations is a clinical problem that doctors and pharma-cists must consider seriously. Neonates are the most physiologically immature and vulnerable to drug dosing.
Wei Zhang +4 more
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International Journal of Nanomedicine, 2018 Ulrika Carlander,1 Tshepo Paulsen Moto,2 Anteneh Assefa Desalegn,1 Robert A Yokel,3 Gunnar Johanson1 1Unit of Work Environment Toxicology, Institute of Environmental Medicine, Karolinska Institutet, Solna, Sweden; 2Faculty of Health Sciences ...
Carlander U +4 more
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Physiologically based pharmacokinetic modeling of zinc oxide nanoparticles and zinc nitrate in mice
International Journal of Nanomedicine, 2015 Wei-Yu Chen,1 Yi-Hsien Cheng,2 Nan-Hung Hsieh,3 Bo-Chun Wu,2 Wei-Chun Chou,4 Chia-Chi Ho,4 Jen-Kun Chen,5 Chung-Min Liao,2,* Pinpin Lin4,* 1Department of Biomedical Science and Environmental Biology, Kaohsiung Medical University, Kaohsiung, 2Department ...
Chen WY +8 more
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Drug Design, Development and Therapy, 2016 Jee Sun Min,1 Doyun Kim,1 Jung Bae Park,1 Hyunjin Heo,1 Soo Hyeon Bae,2 Jae Hong Seo,1 Euichaul Oh,1 Soo Kyung Bae1 1Integrated Research Institute of Pharmaceutical Sciences, College of Pharmacy, The Catholic University of Korea, Bucheon, 2Department of
Min JS +7 more
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Applications of physiologically based pharmacokinetic modeling for the optimization of anti-infective therapies [PDF]
, 2015 Introduction: The pharmacokinetic properties of anti-infective drugs are a determinant part of treatment success. Pathogen replication is inhibited if adequate drug levels are achieved in target sites, whereas excessive drug concentrations linked to ...
Rajoli, Rajith K. R. +3 more
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Physiologically Based Pharmacokinetic Modeling of Nanoparticles [PDF]
Journal of Pharmaceutical Sciences, 2019 Nanoparticles are frequently designed to improve the pharmacokinetics profiles and tissue distribution of small molecules to prolong their systemic circulation, target specific tissue, or widen the therapeutic window. The multifunctionality of nanoparticles is frequently presented as an advantage but also results in distinct and complicated in vivo ...
Dongfen, Yuan +4 more
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MEGen: a physiologically based pharmacokinetic model generator [PDF]
Frontiers in Pharmacology, 2011 Physiologically based pharmacokinetic models are being used in an increasing number of different areas. However, they are perceived as complex, data hungry, resource intensive, and time consuming. In addition, model validation and verification are hindered by the relative complexity of the equations.
Loizou, George, Hogg, Alex
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