Results 21 to 30 of about 23,888,926 (291)

Physiologically Based Pharmacokinetic (PBPK) Models for Ethanol [PDF]

IEEE Transactions on Biomedical Engineering, 2008
Physiologically based pharmacokinetic models have been used to describe the distribution and elimination of ethanol after intravenous administration. These models have been used to estimate the ethanol infusion profile that is sufficient for achieving a prescribed breath ethanol concentration time course in individuals, providing a useful platform for ...
Martin H. Plawecki, Jae-Joon Han, Peter C. Doerschuk, Vijay A. Ramchandani, Sean J. O'Connor   +4 more
openaire   +3 more sources

Physiologically based pharmacokinetic modeling of intravenously administered nanoformulated substances [PDF]

, 2022
The use of nanobiomaterials (NBMs) is becoming increasingly popular in the field of medicine. To improve the understanding on the biodistribution of NBMs, the present study aimed to implement and parametrize a physiologically based pharmacokinetic (PBPK)
Minnema, Jordi, Vandebriel, Rob J., Vandebriel, R, Delmaar, Christiaan, Minnema, J, Delmaar, C, Borgos, SEF, Liptrott, N, Borgos, Sven Even F., Vandebriel, Rob, Borgos, Sven Even F, Liptrott, Neill   +11 more
core   +1 more source

An integrated exposure and pharmacokinetic modeling framework for assessing population-scale risks of phthalates and their substitutes

Environment International, 2021
To effectively incorporate in vitro-in silico-based methods into the regulation of consumer product safety, a quantitative connection between product phthalate concentrations and in vitro bioactivity data must be established for the general population ...
Yaoxing Wu, Zidong Song, John C. Little, Min Zhong, Hongwan Li, Ying Xu   +5 more
doaj   +1 more source

Examination of Physiologically‐Based Pharmacokinetic Models of Rosuvastatin [PDF]

CPT: Pharmacometrics & Systems Pharmacology, 2020
Physiologically‐based pharmacokinetic (PBPK) modeling is increasingly used to predict drug disposition and drug–drug interactions (DDIs). However, accurately predicting the pharmacokinetics of transporter substrates and transporter‐mediated DDIs (tDDIs) is still challenging. Rosuvastatin is a commonly used substrate probe in DDI risk assessment for new
Bowman, Christine M., Ma, Fang, Mao, Jialin, Chen, Yuan   +3 more
openaire   +2 more sources

Development of Successful Physiologically-Based Pharmacokinetic (PBPK) Models [PDF]

, 2023
Physiologically-based pharmacokinetic (PBPK) modeling is a strong mathematical tool that integrates body physiology, drug physicochemical properties and pharmacokinetics to predict detailed drug profiles in different parts of the body.
Nasir Mohammad Yasir Idkaidek, Idkaidek, Nasir Mohammad Yasir   +1 more
core   +1 more source

Vinblastine pharmacokinetics in mouse, dog, and human in the context of a physiologically based model incorporating tissue‐specific drug binding, transport, and metabolism

Pharmacology Research & Perspectives, 2023
Vinblastine (VBL) is a vinca alkaloid‐class cytotoxic chemotherapeutic that causes microtubule disruption and is typically used to treat hematologic malignancies. VBL is characterized by a narrow therapeutic index, with key dose‐limiting toxicities being
Sandra Witta, Keagan P. Collins, Dominique A. Ramirez, Joshua D. Mannheimer, Luke A. Wittenburg, Daniel L. Gustafson   +5 more
doaj   +1 more source

An introduction to physiologically‐based pharmacokinetic models

Pediatric Anesthesia, 2016
SummaryPhysiologically‐based pharmacokinetic (PBPK) models represent drug kinetics in one or more ‘real’ organs (and hence require submodels of organs/tissues) and they describe ‘whole‐body’ kinetics by joining together submodels with drug transport by blood flow as dictated by anatomy.
Richard N. Upton, David J.R. Foster, Ahmad Y. Abuhelwa   +2 more
openaire   +3 more sources

In-Depth Analysis of Physiologically Based Pharmacokinetic (PBPK) Modeling Utilization in Different Application Fields Using Text Mining Tools

Pharmaceutics, 2022
In the past decade, only a small number of papers have elaborated on the application of physiologically based pharmacokinetic (PBPK) modeling across different areas. In this review, an in-depth analysis of the distribution of PBPK modeling in relation to
Aleksandra Krstevska, Jelena Đuriš, Svetlana Ibrić, Sandra Cvijić   +3 more
doaj   +1 more source

The emerging role of physiologically-based pharmacokinetic/biopharmaceutics modeling in formulation development [PDF]

Arhiv za farmaciju, 2021
Computer-based (in silico) modeling & simulation tools have been embraced in different fields of pharmaceutics for a variety of applications. Among these, physiologically-based pharmacokinetic/biopharmaceutics modeling (PBPK/PBBM) emerged as a ...
Cvijić Sandra, Ignjatović Jelisaveta, Parojčić Jelena, Ibrić Svetlana   +3 more
doaj   +1 more source

Physiologically Based Pharmacokinetic Modeling Is Essential in 90Y-Labeled Anti-CD66 Radioimmunotherapy. [PDF]

PLoS ONE, 2015
Radioimmunotherapy (RIT) with 90Y-labeled anti-CD66 antibody is used to selectively irradiate the red marrow (RM) before blood stem cell transplantation of acute leukemia patients.
Peter Kletting, Christian Maaß, Sven Reske, Ambros J Beer, Gerhard Glatting   +4 more
doaj   +1 more source