Results 91 to 100 of about 221,720 (298)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Designing a human-AI collaborative model for precision teaching in undergraduate physiology laboratory education: a modified Delphi study

Advances in Physiology Education
Artificial intelligence (AI) offers new possibilities for enhancing precision in undergraduate physiology laboratory education. However, ethical, pedagogical, and technical challenges remain in designing human-AI collaborative models. This study aimed to
Haozhen Wu, Yunyi Liu, Min Cui, Xinyuan Cao, Yibiao Yuan   +4 more
doaj   +1 more source

Unpacking the “movement of substances” core concept of physiology by an Australian team

, 2023
Australia-wide consensus was reached on seven core concepts of physiology. The “movement of substances” core concept with the descriptor “the movement of substances (ions or molecules) is a fundamental process that occurs at all levels of organization in
Kathy Tangalakis, Moro, Christian, Hryciw, Deanne H, Task Force, Hayes, Alan, Uebergang, Tanya, Alan Hayes, Louise Lexis, Lexis, Louise, Nicole Masters, Brown, Daniel, Towstoless, Michelle, Michelle Towstoless, Daniel Brown, Deanne H. Hryciw, Hryciw, Deanne H., Tangalakis, Kathy, Masters, Nicole, Tanya Uebergang   +18 more
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Support for core concept teaching in an integrated medical school curriculum: student perception and transfer of physiology understanding

Advances in Physiology Education
Core concept teaching has been celebrated in the physiology education community as a strategy to help increase students’ depth of understanding and ability to transfer knowledge to newly encountered contexts.
Mary M. Pelkowski, Gabi N. Waite
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

More than a module of autonomic function tests: student perceptions of a skill-based physiology elective

Advances in Physiology Education
Autonomic function testing (AFT) is crucial for assessing autonomic nervous system integrity and diagnosing dysautonomia. However, AFT remains underrepresented in undergraduate physiology curricula worldwide.
Dhiren Punja, Akash Tomar, Sucharita Sambashivaiah   +2 more
doaj   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Human physiology.

, 2008
newsep2013.xxviii, 770 p. :"Vander's Human Physiology, Twelfth Edition, carries on the tradition of clarity and accuracy, while refining and updating the content to meet the needs of today's instructors and students.
Vander, Arthur J., 1933-, Raff, Hershel, 1953-, Widmaier, Eric P., Strang, Kevin T.   +3 more
core  

Physiology of Saliva: An Overview

, 2014
Physiology of saliva evolves in supporting many important activities in human life. Changes in age, environmental and living condition as well as eating habit would influence salivary function.
Pandey, Abhay Kumar; Department of Physiology, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005
core   +1 more source