Results 101 to 110 of about 221,720 (298)

Unpacking the renal system component of the “structure and function” core concept of physiology by an Australian team

, 2023
An Australia-wide consensus was reached on seven core concepts of physiology, one of which was “structure and function” with the descriptor “Structure and function are intrinsically related to all levels of the organism. In all physiological systems, the
Kathy Tangalakis, Moro, Christian, Hryciw, Deanne H, Task Force, Melissa S. Cameron, Hayes, Alan, Alan Hayes, Perry, Ben, Ben D. Perry, Matthew B. Cooke, Louise Lexis, Lexis, Louise, Cooke, Matthew B, Towstoless, Michelle, Cameron, Melissa, Michelle Towstoless, Deanne H. Hryciw, Hryciw, Deanne H., Tangalakis, Kathy   +18 more
core   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Physiology education and the linguistic jungle of science

Advances in Physiology Education, 2008
proteins, activators, transcription factors, genes, and more proteins. Life sciences can be complicated enough without getting into the names of all its Dalton-scale participants. For many students, composing a project plan or writing a paper is rather like learning a foreign language ...
openaire   +2 more sources

Physiology Educational Research Consortium

, 1998
The Physiology Educational Research Consortium (PERC) is a collaborative research and development effort among 13 physiologists and physiology educators representing 12 post-secondary institutions, ranging from community colleges to medical schools. PERC

core  

The case of thyroid hormones: how to learn physiology by solving a detective case

, 2011
Lellis-Santos C, Giannocco G, Nunes MT. The case of thyroid hormones: how to learn physiology by solving a detective case. Adv Physiol Educ 35: 219-226, 2011; doi:10.1152/advan.00135.2010.Thyroid diseases are prevalent among endocrine disorders, and ...
Camilo Lellis-Santos, Gisele Giannocco, LELLIS-SANTOS, Camilo, Maria Tereza Nunes, GIANNOCCO, Gisele, NUNES, Maria Tereza   +5 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Developing a model renal corpuscle to illustrate concepts in renal physiology

Advances in Physiology Education
Models that illustrate renal fluid dynamics are scarce within the secondary and postsecondary landscape. This work summarizes the efforts to build a rudimentary model renal corpuscle (MRC) that can be employed in a problem-based learning exercise or ...
Jacob E. Hansen, Jonathan A. Chickering, Amy J. Sullivan, Zachary E. Stelter   +3 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source