Antimuscarinic Toxicity Safely Managed with High-Dose Transdermal Rivastigmine: A Case Report [PDF]
Clinical Practice and Cases in Emergency MedicineIntroduction: Antimuscarinic toxicity, which can cause delirium and unsafe behavior, may result from an adverse effect of prescribed medications or from non-medical substance use.
C. James Watson +2 more
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EEG Time-Frequency Clustering Reveals Spectral Signatures of Glutamatergic and Cholinergic Activities and Their Interrelations [PDF]
BiomedicinesBackground: The discovery of electroencephalogram (EEG) biomarkers of direct transmitter–receptor interactions in studies of neurotransmitter mechanisms underlying brain function remains relevant.
Vasily Vorobyov, Alexander Deev
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Treating Diphenhydramine Overdose: A Literature Review of Currently Available Treatment Methods [PDF]
ToxicsFrom 2019 to 2020, antihistamines were found in 15% of all US drug overdose deaths, often co-administered with fentanyl, with 3.6% of overdose deaths due to antihistamines alone.
Jayna Patel, Joshua Edwards
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Anticholinergic toxidrome due to thorn apple seed ingestion in an elderly couple [PDF]
European Journal of Case Reports in Internal MedicineIntroduction: Sudden onset of reduced consciousness, psychomotor agitation and mydriasis are all indicative of an anticholinergic toxidrome. It is important to note that numerous drugs, as well as certain herbs and plants, possess anticholinergic ...
Pepijn van Gastel +4 more
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Massive Atropine Eye Drop Ingestion Treated with High-Dose Physostigmine to Avoid Intubation [PDF]
Western Journal of Emergency Medicine, 2012 Case: A 34-year-old male presented after ingesting 150 mg of atropine. He had altered mental status, sinus tachycardia, dry mucosa, flushed skin, and hyperthermia.
Samuel J. Stellpflug +4 more
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In vitro and in-vivo exploration of physostigmine analogues to understand the mechanistic crosstalk between Klotho and targets for epilepsy [PDF]
Frontiers in PharmacologyBackgroundEpilepsy and seizures are characterized by neuronal hyperexcitability and damage, influenced by metabolic dysregulation, neuroinflammation, and oxidative stress.
Mansi Dahalia +11 more
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Therapeutic effects of physostigmine during systemic inflammation
Journal of Inflammation Research, 2018 Katharina Effenberger-Neidnicht,1 Johannes Jägers,2 Rabea Verhaegh,1 Michael Kirsch1 1Institute of Physiological Chemistry, University Hospital Essen, Essen, Germany; 2Institute of Physiology, University Hospital Essen, Essen, Germany Introduction ...
Effenberger-Neidnicht K +3 more
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Physostigmine as an antinociceptive agent: a possible way to improve the safety of anesthesia
Безопасность и риск фармакотерапии, 2018 Search for new safe analgesics is an urgent task that will increase the safety and efficiency of anesthesia. The aim of this study was to investigate the analgesic effect of intrathecally administered physostigmine.
A. . Nemirovsky
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Characterisation of the N-Methyltransferase SgPsmC: Application in the Kinetic Resolution of Pyrroloindolines. [PDF]
Angew Chem Int Ed EnglThe N‐methyltransferase SgPsmC was characterised and applied in the kinetic resolution (KR) of easily obtainable pyrroloindolines. Substitution at 3a‐position proved to be a principal determinant for the enzyme's enantioselectivity. While moving toward laboratory scale, the reaction was coupled with a methionine adenosyl transferase for in situ ...
Chapple BP +7 more
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