Results 21 to 30 of about 7,017 (216)
Pharmacokinetics of Double-Layer Patches With Microneedles Containing Procyclidine and Rivastigmine in Guinea Pigs. [PDF]
Basic Clin Pharmacol ToxicolABSTRACT Reversible cholinesterase inhibitors have been investigated to address prophylactic and therapeutic outcomes against organophosphorus nerve poisoning, and procyclidine is concomitantly used to compensate for their adverse effects. We designed double‐layer patches with microneedles composed of a cream layer for immediate release and a ...
Moon M +6 more
europepmc +2 more sources
Toxicology Communications, 2022 Glycopyrronium is an antimuscarinic drug that is available in a moist towelette preparation for the treatment of primary axillary hyperhidrosis, which is characterized by excessive sweating on the palms, soles of feet, and axillary region. Antimuscarinic
Sarah Mahonski +3 more
doaj +1 more source
Toxicology Communications, 2023 Treatment of antimuscarinic toxicity has become more difficult in the United States due to an ongoing national shortage of physostigmine. Rivastigmine has emerged as an alternative, off-label therapy due to its similar mechanism of action as a reversible,
Matthew S. Correia +1 more
doaj +1 more source
Anticholinergic syndrome in a patient with schizophrenia
European Psychiatry, 2022 Introduction Anticholinergic syndrome (AS) is a complication that can appear due to different drugs with antimuscarinic effects, such as antihistamines, alkaloids, antipsychotics, tricyclic antidepressives or anesthetics, and it is characterized by ...
O. Marco Estrada +5 more
doaj +1 more source
Hyoscine butylbromide induced psychosis: A case report
Clinical Case Reports, 2022 Hyoscine butylbromide–induced pyschosis, though rare, should be considered in a child presenting with deteriorating cognitive functions and psychotic features acutely as evident in our case of a 9‐year‐old child taking hyoscine for her non‐specific ...
Nimesh Lageju +3 more
doaj +1 more source
Application of Vicarious Nucleophilic Substitution to the Total Synthesis of dl-Physostigmine
, 2016 A concise, highly efficient formal total synthesis of dl-physostigmine is described, using a relatively simple method that should be adaptable to the synthesis of homologous members of this type of alkaloid.
Pankaj D. Rege (2536939) +1 more
core +2 more sources
Central anticholinergic syndrome (CAS) in anesthesiology: a narrative review
Perioperative Medicine, 2019 Psychomotor excitation, delayed recovery of consciousness after general anesthesia – well-known conditions. But only in the literature of Germany, it was first isolated in a separate central anticholinergic syndrome (CAS). This article discusses the main
Dmytro Dmytriiev, Dmytro Bortnik
doaj +1 more source
Delirium due to Anticholinergic Intoxication and Use of Physostigmine in Pediatric Emergency Room
Journal of Pediatric Emergency and Intensive Care Medicine, 2022 Anticholinergics are substances that antagonize the activity of the neurotransmitter acetylcholine. Anticholinergic syndrome (AS) occurs following a suicidal overdose, accidental drug intake, drug incompatibilities, and intake of multiple drugs ...
Alper Çiçek +7 more
doaj +1 more source
Acetylcholinesterase inhibitors reduce neuroinflammation and -degeneration in the cortex and hippocampus of a surgery stress rat model. [PDF]
PLoS ONE, 2013 Exogenous stress like tissue damage and pathogen invasion during surgical trauma could lead to a peripheral inflammatory response and induce neuroinflammation, which can result in postoperative cognitive dysfunction (POCD).
Alexander Kalb +7 more
doaj +1 more source
The Role of Dexmedetomidine in Pediatric Patients Presenting with an Anticholinergic Toxidrome
Case Reports in Critical Care, 2021 Background. We report two pediatric cases of anticholinergic toxidrome, including the youngest reported to date, in which standard therapeutic strategies were either contraindicated or ineffective, while treatment with dexmedetomidine was rapidly ...
Mitchell Zekhtser +3 more
doaj +1 more source