Results 41 to 50 of about 7,017 (216)

On The Innervation of Salivary Glands and Treatment of Dry Mouth - An Experimental and Clinical Study

open access: yes, 2009
Detailed knowledge of the innervation of the parotid gland is essential in basic studies on various neuroglandular phenomena as well as in various types of orofacial surgery. The innervation is more complex than usually depicted in Textbooks.
Khosravani, Nina
core   +1 more source

Mary Broadfoot Walker: 83 years since a historical discovery

open access: yesArquivos de Neuro-Psiquiatria
Mary Broadfoot Walker was a Scottish physician who, in 1935, described in great detail the effect of an anticholinesterase drug (physostigmine) on the signs and symptoms of myasthenia gravis.
Vitor Martinez de Carvalho   +3 more
doaj   +1 more source

Vacuolization as a Novel Approach to Cancer Therapy

open access: yesJournal of Biochemical and Molecular Toxicology, Volume 40, Issue 6, June 2026.
This review discusses the novel strategy of inducing vacuole formation in cancer cells using small molecules, that induce nonapoptotic cell death mechanisms, such as paraptosis, oncosis, autophagy, and methuosis, and its potential in overcoming resistance to apoptosis‐based cancer therapies.
Mariah Pasternak   +9 more
wiley   +1 more source

Physostigmine-induced cerebral protection against hypoxia.

open access: yes, 1979
Physostigmine, at 0.1, 0.2 and 0.3 mg/kg, was tested for effect on the survival of mice exposed to 5% O2-95% N2. Some treated animals survived for one hour under the hypoxic atmosphere (2 out of 14 at 0.1 mg/kg and 8 out of 28 at 0.2 and 0.3 mg/kg), an ...
A M Scremin, O U Scremin
core   +1 more source

Myasthenic Crisis in a Child: Successful Recovery after Early Identification and Intervention

open access: yesIndian Pediatrics Case Reports
Background: Juvenile myasthenia gravis (MG) is a rare autoimmune neuromuscular disorder and has a varied presentation in childhood making it a diagnostic challenge.
Ishmeet Kaur Jaggi   +4 more
doaj   +1 more source

Combined Pre- and Posttreatment of Paraoxon Exposure

open access: yesMolecules, 2020
Aims: Organophosphates (OPCs), useful agents as pesticides, also represent a serious health hazard. Standard therapy with atropine and established oxime-type enzyme reactivators is unsatisfactory.
Dietrich E Lorke   +4 more
doaj   +1 more source

Restoring Septohippocampal Cholinergic Signaling Rescues Surgery‐Induced Neurogenesis and Memory Deficits in Aged Mice

open access: yesAging Cell, Volume 25, Issue 6, June 2026.
Surgery‐induced MS/vDB → DG cholinergic decline impairs hippocampal neurogenesis and memory in aged mice; galantamine‐mediated cholinergic potentiation or sustained chemogenetic activation rescues these deficits, highlighting therapeutic potential for POCD.
Lei Lei   +8 more
wiley   +1 more source

Physostigmine-loaded liposomes for extended prophylaxis against nerve agent poisoning

open access: yes, 2018
Pre-administration of physostigmine can prevent poisoning against nerve agent exposure by reversibly binding to cholinesterase. However, its cholinesterase protection-based prophylactic effect can be eliminated rapidly due to short biological half-life ...
Cho, Hyun-Jong   +6 more
core   +1 more source

Physostigmine and Methylphenidate Induce Distinct Arousal States During Isoflurane General Anesthesia in Rats [PDF]

open access: yes, 2016
BACKGROUND: Although emergence from general anesthesia is clinically treated as a passive process driven by the pharmacokinetics of drug clearance, agents that hasten recovery from general anesthesia may be useful for treating delayed emergence ...
Jonathan D. Kenny   +17 more
core   +1 more source

Indirect cholinergic activation slows down pancreatic cancer growth and tumor-associated inflammation

open access: yesJournal of Experimental & Clinical Cancer Research, 2020
Background Nerve-cancer interactions are increasingly recognized to be of paramount importance for the emergence and progression of pancreatic cancer (PCa).
Paulo L. Pfitzinger   +17 more
doaj   +1 more source

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