Results 61 to 70 of about 7,017 (216)
Multimodal Cross‐Attentive Graph‐Based Framework for Predicting In Vivo Endocrine Disruptors
Advanced Science, Volume 13, Issue 21, 13 April 2026.A multimodal cross‐attentive graph neural network integrates molecular graphs with androgen and estrogen adverse outcome pathway (AOP)–anchored in vitro assay signals to predict in vivo endocrine disruption. By fusing information on Tier‐1 AOP logits with chemical structures, the framework achieves high accuracy and provides assay‐traceable ...
Eder Soares de Almeida Santos +6 more
wiley +1 more source
The antinociceptive activities of oxotremorine, physostigmine and dyflos
, 1972 Oxotremorine and physostigmine caused dose-related increases in the hot plate reaction time (HPRT) of mice, but dyflos did not. Physostigmine did not potentiate a low dose of oxotremorine (0.025 mg/kg) in the HPRT test, but some potentiation of higher ...
S J THA, B COX
core +1 more source
Acta Medica Iranica, 2018 Organophosphates (OPs) and carbamates are acetylcholine esterase inhibitors (AChEIs), which can cause seizure and lethality. Anticonvulsant properties of potassium channel openers including cromakalim have been determined in previous studies.
Sattar Ostadhadi +4 more
doaj
Chemistry &Biodiversity, Volume 23, Issue 4, April 2026.The graphical abstract illustrates the flowchart for the isolation and evaluation of bioactive compounds from Hedychium coronarium. Crude extracts were obtained via cold percolation from the aerial parts (flowers, leaves, and stems) using dichloromethane (DCM) and from the rhizomes using chloroform.
Riddhiman Lahiri +10 more
wiley +1 more source
Transdermal Delivery of Physostigmine. A Pretreatment Against Organophosphate Poisoning
, 1995 Physostigmine absorption through isolated human skin and inhibition of plasma and red blood cell cholinesterases in guinea-pigs have been measured to assess the feasibility of its transdermal delivery as a pretreatment for organophosphate poisoning.
A Saleem, J Jenner, D Swanston
core +1 more source
Interactions of Paraoxonase-1 with Pharmacologically Relevant Carbamates
Molecules, 2020 Mammalian paraoxonase-1 hydrolyses a very broad spectrum of esters such as certain drugs and xenobiotics. The aim of this study was to determine whether carbamates influence the activity of recombinant PON1 (rePON1).
Anita Bosak +5 more
doaj +1 more source
Addiction Biology, Volume 31, Issue 4, April 2026.This study examined the effects of donepezil on mesolimbic dopamine signalling and alcohol‐related behaviours in male rats. Donepezil increases nucleus accumbens dopamine via muscarinic mechanisms and prevented further dopamine elevation after alcohol administration. Although it did not reduce regular alcohol intake, it abolished relapse‐like drinking.
Anna Loftén +4 more
wiley +1 more source
, 1988 Antagonistic effects of physostigmine on ketamine-induced anesthesia and analgesia were studied in male Sprague-Dawley rats using behavioral tests. Rats were divided into six groups.
御村, 光子
core +1 more source
Journal of Enzyme Inhibition and Medicinal Chemistry, 2021 For more than two decades, the development of potent acetylcholinesterase (AChE) inhibitors has been an ongoing task to treat dementia associated with Alzheimer’s disease and improve the pharmacokinetic properties of existing drugs. In the present study,
Benoit David +4 more
doaj +1 more source
Angewandte Chemie, Volume 138, Issue 2, 9 January 2026.Die N‐Methyltransferase SgPsmC wurde charakterisiert und für die kinetische Racematspaltung von Pyrroloindolinen verwendet. Die Substitution an 3a‐Position erwies sich als eine Hauptdeterminante für die Enantioselektivität des Enzyms. Die Reaktion wurde mit einer Methionin‐Adenosyl‐Transferase gekoppelt, um S‐Adenosylmethionin in situ zu erzeugen und ...
Benjamin Panagiotis Chapple +7 more
wiley +1 more source