Results 151 to 160 of about 130,545 (289)

The emerging role of Nrf2 in heart failure: From cardioprotection to therapeutic approaches

open access: yesESC Heart Failure, EarlyView.
Nrf2 signalling is impaired in heart failure, contributing to oxidative stress, mitochondrial dysfunction, and ferroptosis, which drive neurohormonal activation, inflammation, and ischaemia‐reperfusion injury. This loss of Nrf2 activity exacerbates hypertension, diabetic cardiomyopathy, and cardiotoxicity, accelerating progression to overt heart ...
Emiliano Fiori   +9 more
wiley   +1 more source

Artificial intelligence in preclinical epilepsy research: Current state, potential, and challenges

open access: yesEpilepsia Open, EarlyView.
Abstract Preclinical translational epilepsy research uses animal models to better understand the mechanisms underlying epilepsy and its comorbidities, as well as to analyze and develop potential treatments that may mitigate this neurological disorder and its associated conditions. Artificial intelligence (AI) has emerged as a transformative tool across
Jesús Servando Medel‐Matus   +7 more
wiley   +1 more source

Hydroxyl Groups on the B Ring of Flavonols Significantly Impact the Energy and Lipid Metabolism in Mice: A Biochemical and Gut Microbiota Approach

open access: yesFood Chemistry International, EarlyView.
The number and position of hydroxyl groups on the B ring of flavonols led to differences in regulating energy metabolism in mice. ABSTRACT In this study, quercetin, myricetin, kaempferol, and morin were compared in context to their ameliorative effects on lipid disorders in high‐fat dietary mice.
Weizhi Zhong   +4 more
wiley   +1 more source

Do honey phytochemicals modulate forager aggression and the gut microbiome in the honey bee (Apis mellifera L.)? [PDF]

open access: yesBiol Open
Pike WA   +7 more
europepmc   +1 more source

Exploring Plant‐Derived Nutraceuticals as Potential SARS CoV‐2 Mpro Inhibitors

open access: yesFood Chemistry International, EarlyView.
The search for plant derived anti‐SARS‐CoV‐2 Mpro compounds starts from food plants and spices as rich sources of bioactive compounds. Both in silico screening and experimental validation are essential to assess their therapeutic potential, leading to candidates for drug development and dietary integration.
Shaza S. Issa, Tatiana V. Matveeva
wiley   +1 more source

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