Results 91 to 100 of about 291,099 (263)

Phytochemicals as a Complement to Cancer Chemotherapy: Pharmacological Modulation of the Autophagy-Apoptosis Pathway

Frontiers in Pharmacology, 2021
Bioactive plant derived compounds are important for a wide range of therapeutic applications, and some display promising anticancer properties. Further evidence suggests that phytochemicals modulate autophagy and apoptosis, the two crucial cellular ...
Md Ataur Rahman, M. Hannan, R. Dash, M. Rahman, Rokibul Islam Shuvo, Md Jamal Uddin, A. Sohag, M. Rahman, H. Rhim   +8 more
semanticscholar   +1 more source

Salvianolic Acid a Disrupts the HSP90α‐AKT‐PERK Ternary Complex to Alleviate Atherosclerosis by Activating Endoplasmic Reticulum Stress of Senescent Vascular Smooth Muscle Cells

Advanced Science, EarlyView.
Salvianolic acid A (SAA) selectively induces senescent vascular smooth muscle cell apoptosis, alleviating atherosclerosis. Mechanistically, SAA targets heat shock protein 90 alpha (HSP90α) to disrupt the protein inase B (AKT)‐PRKR‐Like Endoplasmic Reticulum Kinase (PERK) scaffold, driving ubiquitin‐proteasome‐dependent AKT degradation.
Xiuya Guan, Mengkai Lu, Xinhai Cui, Dawei Zhang, Lei Zhang, Lin Lin, Yuan Li, Yuanlong Hu, Chao Li   +8 more
wiley   +1 more source

Biphasic Dose-Response Induced by Phytochemicals: Experimental Evidence

Journal of Clinical Medicine, 2020
Many phytochemicals demonstrate nonmonotonic dose/concentration-response termed biphasic dose-response and are considered to be hormetic compounds, i.e., they induce biologically opposite effects at different doses.
J. Jodynis-Liebert, M. Kujawska
semanticscholar   +1 more source

Phytochemicals targeting NF-κB signaling: Potential anti-cancer interventions

Journal of Pharmaceutical Analysis, 2021
Nuclear factor κB (NF-κB) is a ubiquitous regulator of the signalome and is indispensable for various biological cell functions. NF-κB consists of five transcription factors that execute both cytoplasmic and nuclear signaling processes in cells. NF-κB is
Akansha Chauhan, A. Islam, Hridayesh Prakash, Sandhya Singh   +3 more
semanticscholar   +1 more source

Oral Recombinant Human Collagen III Protects Gastric Mucosa via G‐Quadruplex‐Mediated Activation of the Pla2g4a‐Prostaglandin Axis

Advanced Science, EarlyView.
Orally administered recombinant human type III collagen protects the gastric mucosa from ethanol‐induced injury by coordinating redox homeostasis, epithelial barrier repair, and arachidonic acid–prostaglandin metabolism. Gastric digestion releases the pentapeptide GPAEF, which interacts with the Pla2g4a promoter G‐quadruplex in a structure‐dependent ...
Xinyue Lan, Qiu Dai, Yanhui Wang, Jiaxuan Gu, Chengyun Wang, Weicheng Xu, Xinru Gao, Jiageng Cheng, Wentao Geng, Xiaowen Wu, Haihang Li, Xiaoyun He, Shengwei Fu, Longjiao Zhu, Wentao Xu   +14 more
wiley   +1 more source

Analysis of Characteristic Aroma Compounds in Six Camellia oleifera Seed Oils

Shipin gongye ke-ji
To screen Camellia oleifera germplasm resources with rich aroma profiles, the aroma components of six cold-pressed Camellia oleifera seed oils were compared, with 'Cenruan 2' serving as the control, and a comprehensive evaluation was conducted by ...
Ruonan LIU, Chunsheng TAN, Jianyou GAO, Kaiyu YE, Rongxiang ZHU, Liming XIA, Cuixia LIU, Faming WANG   +7 more
doaj   +1 more source

Genetic diversity and population structure of the narrow endemic and endangered species Heteroplexis microcephala Y. L. Chen. in China revealed by random amplified polymorphic DNA markers [PDF]

Archives of Biological Sciences, 2016
Heteroplexis microcephala Y. L. Chen. is an endemic and endangered species found only in karst limestone regions in the Yangshuo County of the Guangxi Zhuang Autonomous Region in China: it is a habitat representative of species in the ...
Shi Yancai, Wei Xiao, Wei Jiqing, Li Yongtao, Chai Shengfeng, Tang Jianming   +5 more
doaj   +1 more source

Hormetic Dietary Phytochemicals [PDF]

NeuroMolecular Medicine, 2008
Compelling evidence from epidemiological studies suggests beneficial roles of dietary phytochemicals in protecting against chronic disorders such as cancer, and inflammatory and cardiovascular diseases. Emerging findings suggest that several dietary phytochemicals also benefit the nervous system and, when consumed regularly, may reduce the risk of ...
Tae Gen, Son, Simonetta, Camandola, Mark P, Mattson   +2 more
openaire   +2 more sources

Ilexoside K Ameliorates Atherosclerosis by Suppressing CD72hi Macrophages and Blocking CXCL12–CXCR4 Axis to Inhibit Endothelial Pyroptosis

Advanced Science, EarlyView.
CD72hi macrophages drive endothelial pyroptosis and accelerate atherosclerosis through CXCL12–CXCR4‐mediated immune–vascular crosstalk. Ilexoside K suppresses this pathogenic communication by modulating CXCR4‐dependent endothelial responses, reducing inflammation and plaque progression. These findings reveal a macrophage–endothelial regulatory axis and
Xingling He, Sijing Li, Jiahui Chen, Liyu Lin, Xinyu Li, Xiaojiao Zhang, Yihui Zhang, Xingling Chen, Jinjian Guo, Zhongqi Yang, Lu Lu, Shihao Ni   +11 more
wiley   +1 more source

Innovative Perspectives on Phytochemicals in Human Nutrition

Phytochemicals are chemical compounds naturally occurring in plants [...
Valentina Melini, Maurizio Ruzzi
core   +1 more source