Results 141 to 150 of about 47,579,310 (326)

Transformation groups on a $K(\pi ,\,1)$. I.

Michigan Mathematical Journal, 1959
Conner, P. E., Montgomery, D.
openaire   +3 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Pi 1 Magnetic Pulsations Observed in Association with Low Latitude Aurora.

Journal of geomagnetism and geoelectricity, 1994
Irregular magnetic pulsations and IPDP plasma wave events related to the low latitude aurora were observed at Yonezawa observatory on October 20 and 21, 1989. Three positive bays appeared in the magnetograms on October 20. Concurrently, IPDP, Pi 2, Pi B and Pi C are registered during the respective positive bays.
openaire   +2 more sources

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

On Banach frameness of degenerate weighted exponential system

Fixed Point Theory and Algorithms for Sciences and Engineering
This work deals with the frameness of weighted exponential system E ( ω , Z ) = { ω ( t ) e i n t } n ∈ Z $E(\omega ,Z)= \left \{\omega (t)e^{int} \right \}_{n\in Z} $ in the space L p ( − π , π ) $L_{p} (-\pi ,\pi )$ , p > 1 $p>1$ , with the weight ...
Migdad I. Ismailov, Kader Simsir Acar
doaj   +1 more source

Quality Assessment of Discarded Human Kidneys Using Normothermic Perfusion

Transplantation Direct
Background. Ex vivo normothermic perfusion (EVNP) allows for comprehensive functional assessment; however, current scoring systems are validated only for short perfusion durations.
Enrique Montagud-Marrahi, MD, PhD, Thomas Prudhomme, MD, PhD, Tarek Ajami, MD, Cristina García-Parejo, MD, Lluis Peri, MD, PhD, Adriana Rodriguez-Gonzalo, BSc, Yosu Luque, MD, PhD, Antoni Vilaseca, MD, PhD, Ruben Rabadan-Ros, PhD, Elena Cuadrado-Payan, MD, Elisenda Bañón-Maneus, PhD, Jordi Rovira, PhD, Maria José Ramírez-Bajo, PhD, Lourdes Mengual, PhD, Mercedes Ingelmo, PhD, Ana Belén Larque, MD, PhD, Antonio Alcaraz, MD, PhD, Josep M. Campistol, MD, PhD, Fritz Diekmann, MD, PhD, Mireia Musquera, MD, PhD   +19 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Pi 1 2 -comprehension and the property of Ramsey

, 2008
Die Eigenschaft von Ramsey wird in der reversen Mathematik genutzt, um die Stärke von Teilsystemen der Zahlentheorie der schwachen zweiten Stufe zu vergleichen. Wir zeigen, dass ein Teilsystem, dessen Stärke durch autonom iterierte Ramseyness bestimmt wird, beweistheoretisch äquivalent ist zu Pi-1-2-Komprehension.
openaire  

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Glutathione S-transferase Pi 1 is a valuable predictor for cancer drug resistance in esophageal squamous cell carcinoma. [PDF]

Cancer Sci, 2019
Ogino S, Konishi H, Ichikawa D, Matsubara D, Shoda K, Arita T, Kosuga T, Komatsu S, Shiozaki A, Okamoto K, Kishimoto M, Otsuji E.   +11 more
europepmc   +1 more source