Results 131 to 140 of about 47,579,310 (326)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

P600: DNA METHYLATION ANALYSIS OF B-CELL PROLYMPHOCYTIC LEUKEMIA REVEALS TWO EPIGENETIC SUBTYPES WITH DISTINCT BIOLOGICAL AND CLINICAL FEATURES

HemaSphere, 2023
Stella Charalampopoulou, Elise Chapiro, Ferran Nadeu, Thorsten Zenz, Silvia Beà, Damien Roos-Weil, Olivier Bernard, Santos A Susin, Estella Matutes, Elias Campo, Martí Duran-Ferrer, Florence Nguyen-Khac, José Ignacio Martín-Subero   +12 more
doaj   +1 more source

PI Debriefing

, 1972
The PI Debriefing for the Skylab Medical Experiments Altitude Test ...

core  

$K(π,1)$ conjecture for Artin groups

, 2012
The purpose of this paper is to put together a large amount of results on the $K(π,1)$ conjecture for Artin groups, and to make them accessible to non-experts. Firstly, this is a survey, containing basic definitions, the main results, examples and an historical overview of the subject.
openaire   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Discovery and validation of frameshift-derived neopeptides in Lynch syndrome: paving the way for novel cancer prevention strategies

Journal for ImmunoTherapy of Cancer
Background Lynch syndrome (LS), caused by germline pathogenic variants in the mismatch repair genes, leads to high rates of frameshift-derived neopeptide (FSDN) expression due to microsatellite instability (MSI).
Marta Pineda, Sabela Carballal, María Pellisé, Liseth Rivero, Francesc Balaguer, Fátima Marín, Leticia Moreira, Teresa Ocaña, Manel Juan, Daniel Benitez-Ribas, Georgina Flórez-Grau, Joaquín Castillo-Iturra, Cristina Bayó, Giancarlo Castellano, Hardeep Kumari, Maria Daca-Alvarez, Oswaldo Ortiz, Rebeca Moreira, Julia Canet-Hermida, Capella Gabriel   +19 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

PB2088: IMMUNE PROFILE OF PATIENTS WITH FOLLICULAR LYMPHOMA ASSESSED BY FLOW CYTOMETRY IN PERIPHERAL BLOOD: CHARACTERISTICS AT DIAGNOSIS AND AT RELAPSE OF THE DISEASE

HemaSphere, 2022
A. Rivero Arango, P. Mozas, J. Correa, A. Rivas-Delgado, F. Araujo-Ayala, K. Guinetti, A. Bataller, M. Condom, A. Gaya, J. Delgado, E. Giné, P. Perez-Galán, E. Campo, A. Vlagea, E. Matutes, A. López-Guillermo, N. Villamor, L. Magnano   +17 more
doaj   +1 more source

Observation of the D-1(2420) -> D pi(+)pi(-) decays [PDF]

, 2005
We report on the first observation of D-1(0)(2420)-> D(0)pi(-)pi(+) and D-1(+)(2420)-> D(+)pi(-)pi(+) decays (where the contribution from the dominant known D-1-> D(*)pi decay mode is excluded) in the B--> D(1)(0)pi(-) and (B) over bar (0)-> D(1)(+)pi(-)
Danilov, M, Brodzicka, J, Kawasaki, T, Tamai, K, Tanaka, M, Nakano, E, Bahinipati, S, Kapusta, P, Villa, S, Bracko, M, Kim, HJ, Tamura, N, Somov, A, Eiges, V, Aihara, H, Tian, XC, Yamaguchi, A, Imoto, A, Bondar, A, Kichimi, H, Tsukamoto, T, Bedny, I, Inami, K, Parslow, N, Kinoshita, K, Schneider, O, Kuo, CC, Okuno, S, Majumder, G, Chang, P, Shwartz, B, Staric, M, Chistov, R, Wang, CC, Kuzmin, A, Adachi, I, Watanabe, M, Kang, JS, Blyth, S, Drutskoy, A, Kang, JH, Stanic, S, Fang, F, Kim, SM, Ueno, K, Wang, CH, Eidelman, S, Zhang, ZP, Chen, KF, Kim, SK, Tajima, O, Chao, Y, Shibuya, H, Hayashii, H, Nagasaka, Y, Dash, M, Ishikawa, A, Kim, JH, Palka, H, Bizjak, I, Hoshi, Y, Miyata, H, Uglov, T, Cheon, BG, Koppenburg, P, Banerjee, S, Hou, S, Lin, SW, Hayasaka, K, Poluektov, A, Kataoka, SU, Chuvikov, A, Yamashita, Y, Golob, B, Leder, G, Nagamine, T, Gokhroo, G, Krizan, P, Ohshima, T, Gabyshev, N, Mizuk, R, Yamauchi, M, Aziz, T, Takasaki, F, Schumann, J, Asano, Y, Fratina, S, Anipko, D, Zhang, J, Sumisawa, K, Uno, S, Hazumi, M, Olsen, SL, Schietinger, T, Bozek, A, MacNaughton, J, Mandl, F, Soni, N, Ozaki, H, Sato, N, Nishida, S, Zontar, D, Zhang, CC, Bitenc, U, Itoh, R, Iwasaki, Y, Iijima, T, Suzuki, SY, Hastings, NC, Garmash, A, Suzuki, S, Okabe, T, Yusa, Y, Matyja, A, Senyo, K, Higuchi, T, Zhilich, V, Hinz, L, Ying, J, Sumiyoshi, T, Nitoh, O, Liventsev, D, Li, J, Kawai, H, Mitaroff, W, Pestotnik, R, Chen, WT, Matsumoto, T, Singh, JB, Hou, WS, Ogawa, S, Korpar, S, Krokovny, P, Katayama, N, Choi, SK, Uehara, S, Varvell, KE, Yabsley, BD, Choi, Y, Sagawa, H, Dalseno, J, Ostrowicz, W, Lee, SH, Chen, A, Bakich, AM, Natkaniec, Z, Haba, J, Park, CW, Piilonen, LE, Akatsu, M, Belle Collaboration, Abe, K, Lesiak, T, Gershon, T, Pakhlov, P, Aushev, T, Seuster, R, Semenov, S, Kwon, YJ, Sakai, Y, Zhang, LM, Hokuue, T, Stamen, R, Teramoto, Y   +163 more
core