Results 121 to 130 of about 916,908 (264)

Quality Assessment of Discarded Human Kidneys Using Normothermic Perfusion

Transplantation Direct
Background. Ex vivo normothermic perfusion (EVNP) allows for comprehensive functional assessment; however, current scoring systems are validated only for short perfusion durations.
Enrique Montagud-Marrahi, MD, PhD, Thomas Prudhomme, MD, PhD, Tarek Ajami, MD, Cristina García-Parejo, MD, Lluis Peri, MD, PhD, Adriana Rodriguez-Gonzalo, BSc, Yosu Luque, MD, PhD, Antoni Vilaseca, MD, PhD, Ruben Rabadan-Ros, PhD, Elena Cuadrado-Payan, MD, Elisenda Bañón-Maneus, PhD, Jordi Rovira, PhD, Maria José Ramírez-Bajo, PhD, Lourdes Mengual, PhD, Mercedes Ingelmo, PhD, Ana Belén Larque, MD, PhD, Antonio Alcaraz, MD, PhD, Josep M. Campistol, MD, PhD, Fritz Diekmann, MD, PhD, Mireia Musquera, MD, PhD   +19 more
doaj   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Pi 1 2 -comprehension and the property of Ramsey

, 2008
Die Eigenschaft von Ramsey wird in der reversen Mathematik genutzt, um die Stärke von Teilsystemen der Zahlentheorie der schwachen zweiten Stufe zu vergleichen. Wir zeigen, dass ein Teilsystem, dessen Stärke durch autonom iterierte Ramseyness bestimmt wird, beweistheoretisch äquivalent ist zu Pi-1-2-Komprehension.
openaire  

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Glutathione S-transferase Pi 1 is a valuable predictor for cancer drug resistance in esophageal squamous cell carcinoma. [PDF]

Cancer Sci, 2019
Ogino S, Konishi H, Ichikawa D, Matsubara D, Shoda K, Arita T, Kosuga T, Komatsu S, Shiozaki A, Okamoto K, Kishimoto M, Otsuji E.   +11 more
europepmc   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Alpha-1 antitrypsin Pi*Z gene frequency and Pi*ZZ genotype numbers worldwide: an update

International Journal of COPD, 2017
Ignacio Blanco,1 Patricia Bueno,2 Isidro Diego,3 Sergio Pérez-Holanda,4 Francisco Casas-Maldonado,5 Cristina Esquinas,6 Marc Miravitlles6,7 1Alpha1-Antitrypsin Deficiency Spanish Registry (REDAAT), Fundación Respira, Spanish Society of ...
Blanco I, Bueno P, Diego I, Pérez-Holanda S, Casas-Maldonado F, Esquinas C, Miravitlles M   +6 more
doaj  

Evaluation of glutathione S-transferase pi 1 expression and gene promoter methylation in Moroccan patients with urothelial bladder cancer. [PDF]

Mol Genet Genomic Med, 2018
Hadami K, Dakka N, Bensaid M, El Ahanidi H, Ameur A, Chahdi H, Oukabli M, Al Bouzidi A, Attaleb M, El Mzibri M.   +9 more
europepmc   +1 more source

A large Pi-1-2 set absolute for set forcing

, 1992
Let k be a definable L-cardinal. Then there is a set of reals X, class-generic over L, such that L(X) and L have the same cardinals, X has size k in L(X) and some pi-1-2 formula defines X in all set-generic extensions of L(X). Two corollaries, both assuming the consistency of an inaccessible: It is consistent for the Perfect Set Property to hold for ...
openaire   +2 more sources

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source