Results 101 to 110 of about 724,503 (248)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
On Banach frameness of degenerate weighted exponential system
Fixed Point Theory and Algorithms for Sciences and EngineeringThis work deals with the frameness of weighted exponential system E ( ω , Z ) = { ω ( t ) e i n t } n ∈ Z $E(\omega ,Z)= \left \{\omega (t)e^{int} \right \}_{n\in Z} $ in the space L p ( − π , π ) $L_{p} (-\pi ,\pi )$ , p > 1 $p>1$ , with the weight ...
Migdad I. Ismailov, Kader Simsir Acar
doaj +1 more source
Quality Assessment of Discarded Human Kidneys Using Normothermic Perfusion
Transplantation DirectBackground. Ex vivo normothermic perfusion (EVNP) allows for comprehensive functional assessment; however, current scoring systems are validated only for short perfusion durations.
Enrique Montagud-Marrahi, MD, PhD +19 more
doaj +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Pi 1 2 -comprehension and the property of Ramsey
, 2008 Die Eigenschaft von Ramsey wird in der reversen Mathematik genutzt, um die Stärke von Teilsystemen der Zahlentheorie der schwachen zweiten Stufe zu vergleichen. Wir zeigen, dass ein Teilsystem, dessen Stärke durch autonom iterierte Ramseyness bestimmt wird, beweistheoretisch äquivalent ist zu Pi-1-2-Komprehension.
openaire
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Glutathione S-transferase Pi 1 is a valuable predictor for cancer drug resistance in esophageal squamous cell carcinoma. [PDF]
Cancer Sci, 2019 Ogino S +11 more
europepmc +1 more source
A large Pi-1-2 set absolute for set forcing
, 1992 Let k be a definable L-cardinal. Then there is a set of reals X, class-generic over L, such that L(X) and L have the same cardinals, X has size k in L(X) and some pi-1-2 formula defines X in all set-generic extensions of L(X). Two corollaries, both assuming the consistency of an inaccessible: It is consistent for the Perfect Set Property to hold for ...
openaire +2 more sources
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source