Results 111 to 120 of about 916,908 (264)
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Journal for ImmunoTherapy of CancerBackground Lynch syndrome (LS), caused by germline pathogenic variants in the mismatch repair genes, leads to high rates of frameshift-derived neopeptide (FSDN) expression due to microsatellite instability (MSI).
Marta Pineda +19 more
doaj +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Transformation groups on a $K(\pi ,\,1)$. I.
Michigan Mathematical Journal, 1959 Conner, P. E., Montgomery, D.
openaire +3 more sources
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Pi 1 Magnetic Pulsations Observed in Association with Low Latitude Aurora.
Journal of geomagnetism and geoelectricity, 1994 Irregular magnetic pulsations and IPDP plasma wave events related to the low latitude aurora were observed at Yonezawa observatory on October 20 and 21, 1989. Three positive bays appeared in the magnetograms on October 20. Concurrently, IPDP, Pi 2, Pi B and Pi C are registered during the respective positive bays.
openaire +2 more sources
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
On Banach frameness of degenerate weighted exponential system
Fixed Point Theory and Algorithms for Sciences and EngineeringThis work deals with the frameness of weighted exponential system E ( ω , Z ) = { ω ( t ) e i n t } n ∈ Z $E(\omega ,Z)= \left \{\omega (t)e^{int} \right \}_{n\in Z} $ in the space L p ( − π , π ) $L_{p} (-\pi ,\pi )$ , p > 1 $p>1$ , with the weight ...
Migdad I. Ismailov, Kader Simsir Acar
doaj +1 more source