Results 81 to 90 of about 47,579,310 (326)

Not all free arrangements are $K(π,1)$

, 1994
We produce a one-parameter family of hyperplane arrangements that are counterexamples to the conjecture of Saito that the complexified complement of a free arrangement is $K(π,1)$. These arrangements are the restriction of a one-parameter family of arrangements that arose in the study of tilings of certain centrally symmetric octagons.
Edelman, Paul H., Reiner, Victor
openaire   +3 more sources

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Molecular Characterization of Hospital- and Community-Acquired Streptococcus agalactiae Isolates among Nonpregnant Adults in Isfahan, Iran

Advanced Biomedical Research, 2020
Background: The increasing incidence of Group B Streptococcus (GBS) infection among nonpregnant adults has become of growing clinical and public health concern.
Tahereh Motallebirad, Hossein Fazeli, Saba Jalalifar, Darioush Shokri, Sharareh Moghim, Bahram Nasr Esfahani   +5 more
doaj   +1 more source

The ${\mathcal K}(\pi ,1)$-conjecture for the affine braid groups

Commentarii Mathematici Helvetici, 2003
The complement of the hyperplane arrangement associated to the (complexified) action of a finite, real reflection group on \mathbb C^n is known to be a {\mathcal K}(\pi ,1)
Ruth Charney, David Peifer
openaire   +2 more sources

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

All-CLL: A Capture-based Next-generation Sequencing Panel for the Molecular Characterization of Chronic Lymphocytic Leukemia

HemaSphere, 2023
Irene López-Oreja, Mónica López-Guerra, Juan Correa, Pablo Mozas, Ana Muntañola, Luz Muñoz, Ana-Camino Salgado, Sílvia Ruiz-Gaspà, Dolors Costa, Sílvia Beà, Pedro Jares, Elías Campo, Dolors Colomer, Ferran Nadeu   +13 more
doaj   +1 more source

Association of large core middle cerebral artery stroke and hemorrhagic transformation with hospitalization outcomes

Scientific Reports
Historically, investigators have not differentiated between patients with and without hemorrhagic transformation (HT) in large core ischemic stroke at risk for life-threatening mass effect (LTME) from cerebral edema.
Jack E. Pohlmann, Ivy So Yeon Kim, Benjamin Brush, Krishna M. Sambhu, Lucas Conti, Hanife Saglam, Katie Milos, Lillian Yu, Michael F. M. Cronin, Oluwafemi Balogun, Stefanos Chatzidakis, Yihan Zhang, Ludovic Trinquart, Qiuxi Huang, Stelios M. Smirnakis, Emelia J. Benjamin, Josée Dupuis, David M. Greer, Charlene J. Ong   +18 more
doaj   +1 more source

Streptococcus agalactiae Causing Neonatal Infections in Portugal (2005–2015): Diversification and Emergence of a CC17/PI-2b Multidrug Resistant Sublineage

Frontiers in Microbiology, 2017
The molecular characterization of 218 GBS isolates recovered from neonatal invasive infections in Portugal in 2005–2015 revealed the existence of a small number of genetically distinct lineages that were present over a significant time-span.
E. Martins, Cristiano Pedroso-Roussado, J. Melo-Cristino, M. Ramirez, Henrique Teresa Marília Rui Ana Cristina Hermínia Maria Fát Oliveira Vaz Gião Ferreira Silva Costa Silva Afons   +4 more
semanticscholar   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source