Results 91 to 100 of about 869,852 (274)
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
Life of Pi: Exploring functions of Pi16+ fibroblasts [version 2; peer review: 2 approved]
F1000ResearchFibroblasts are mesenchymal cells that are responsible for creating and maintaining tissue architecture through the production of extracellular matrix. These cells also play critical roles in processes such as wound repair and immune modulation in normal
Yein Chung +2 more
doaj +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
European Physical Journal C: Particles and FieldsThe departure of the latest FNAL experimental average for the muon anomalous magnetic moment $$a_\mu =(g_\mu -2)/2$$ a μ = ( g μ - 2 ) / 2 measurements, having increased from $$4.2 \sigma $$ 4.2 σ (Abi et al. in Measurement of the positive muon anomalous
M. Benayoun, L. DelBuono, F. Jegerlehner
doaj +1 more source
Algorithms, 2018 A k-colouring of a graph G with colours 1 , 2 , … , k is canonical with respect to an ordering π = v 1 , v 2 , … , v n of the vertices of G if adjacent vertices are assigned different colours and, for 1 ≤ c ≤ k
Ruth Haas, Gary MacGillivray
doaj +1 more source
Low-energy excitations around (\pi/2, \pi/2) points in the pseudogap phase of Nd_1.85Ce_0.15CuO_4
, 2003 Polarized electronic Raman scattering from the NCCO superconductor at optimal electron doping (T_c=22 K) reveals the formation of an anisotropic pseudogap below a characteristic temperature T* ~ 220 K and energy E*_g = 850 cm-1. Below T* a pronounced suppression of the incoherent spectral weight below E*_g in the nodal directions of k-space is observed.
Koitzsch, A. +5 more
openaire +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source