Results 111 to 120 of about 880,343 (275)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

PB2088: IMMUNE PROFILE OF PATIENTS WITH FOLLICULAR LYMPHOMA ASSESSED BY FLOW CYTOMETRY IN PERIPHERAL BLOOD: CHARACTERISTICS AT DIAGNOSIS AND AT RELAPSE OF THE DISEASE

HemaSphere, 2022
A. Rivero Arango, P. Mozas, J. Correa, A. Rivas-Delgado, F. Araujo-Ayala, K. Guinetti, A. Bataller, M. Condom, A. Gaya, J. Delgado, E. Giné, P. Perez-Galán, E. Campo, A. Vlagea, E. Matutes, A. López-Guillermo, N. Villamor, L. Magnano   +17 more
doaj   +1 more source

Automated detection of Pi 2 pulsations using wavelet analysis: 2. An application for dayside Pi 2 pulsation study

Earth, Planets and Space, 2014
We investigated statistical characteristics of dayside Pi 2 pulsations observed at Mineyama (25.5° geomagnetic latitude) from November 1994 through June 1996, using an algorithm to detect Pi 2 pulsations which was introduced in Part 1 of the accompanying paper. We obtained the following results.
openaire   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Correction to: Chikungunya outbreak in Bangladesh (2017): sociodemographic and clinical characteristics of patients from three hotspots

Tropical Medicine and Health, 2022
Mohammad Robed Amin, Mohammad Jahid Hasan, Md. Abdullah Saeed Khan, Md Abdur Raf, Mohammad Rafiqul Islam, Tarek Shams, Mohammed Jahedul Islam, Abu Saif Mohammad Lutful Kabir, Mohiuddin Sharif, David Gozal   +9 more
doaj   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Unified study of $$B_s^0 \rightarrow X(3872) \pi ^+\pi ^- (K^+ K^-)$$ B s 0 → X ( 3872 ) π + π - ( K + K - ) and $$B_s^0 \rightarrow \psi (2S) \pi ^+\pi ^- (K^+ K^-)$$ B s 0 → ψ ( 2 S ) π + π - ( K + K - ) processes

European Physical Journal C: Particles and Fields
We perform a unified description of the experimental data of the $$\pi ^+\pi ^-$$ π + π - invariant mass spectra of $$B_s^0 \rightarrow \psi (2S) \pi ^+\pi ^-$$ B s 0 → ψ ( 2 S ) π + π - , the $$\pi ^+\pi ^-$$ π + π - and $$K^+ K^-$$ K + K - invariant ...
Yun-Hua Chen
doaj   +1 more source

An Eulerian Method for Representing $\pi^2$ by Series

Rocky Mountain Journal of Mathematics, 1992
By using a method attributed to Euler, the author proves three series representations for \(\pi^ 2\). For example, \(\pi^ 2=12-16 \sum^{+\infty}_{k=1} 1/(2k-1)(2k+1)^ 2\). The method can be summarized as follows: Evaluate e.g. the integral \(\int^ x_ 0 \sqrt{1-t^ 2} dt\) directly, and then by expanding the integrand, followed by termwise integration ...
openaire   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source