Results 221 to 230 of about 13,469,882 (326)

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

open access: yesFEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp   +13 more
wiley   +1 more source

Calcium‐sensing receptor induces the apoptosis of chondrocytes in cooperation with phosphate transporter

open access: yesFEBS Open Bio, EarlyView.
Excess Ca2+ ions activate the Calcium‐Sensing Receptor (CaSR), which subsequently drives the uptake of excess inorganic phosphate (Pi) via the Pi transporter (Pit−1) in chondrocytes. This mechanism causes a toxic increase in intracellular Pi concentration, ultimately leading to chondrocyte apoptosis and pathological mineralization. Excess extracellular
Sachie Nakatani   +7 more
wiley   +1 more source

Design considerations for photoinitiator selection in cell-laden gelatin methacryloyl hydrogels. [PDF]

open access: yesBiomater Sci
Dogan E   +5 more
europepmc   +1 more source

The photoswitchable cannabinoid azo‐HU308 enables optical control of Ca2+ dynamics in INS‐1 β‐cells via off‐target effects on TRPC channels

open access: yesFEBS Open Bio, EarlyView.
Light activation of the photoswitchable cannabinoid ligand azo‐HU308 triggers Ca2+ influx in pancreatic β‐cells through TRPC channels, independent of CB2 cannabinoid receptors. This reveals a non‐GPCR pathway for cannabinoid modulation of β‐cell Ca2+ dynamics and establishes azo‐HU308 as an optical tool to study cannabinoid signaling through TRP ...
Alexander E. G. Viray, James A. Frank
wiley   +1 more source

Biomolecular condensates sustain pH gradients at equilibrium through charge neutralization. [PDF]

open access: yesNat Chem
Ausserwöger H   +18 more
europepmc   +1 more source

SmallTalk: a novel small‐sized fusion tag for peptide expression and purification

open access: yesFEBS Open Bio, EarlyView.
The SmallTalk fusion tag allows for the efficient expression and purification of soluble recombinant proteins or peptides in Escherichia coli. Testing with SmallTalk‐GFP confirmed that the proteins were soluble and folded correctly, while SmallTalk‐Bin1b maintained its antimicrobial activity against various bacterial isolates. This streamlined workflow
Atika Tariq   +3 more
wiley   +1 more source

Corrigendum to "Previous institutionalization is associated with elevated functional connectivity between the nucleus accumbens and amygdala during aversive learning" [Dev. Cognit. Neurosci. 76 (2025), 101617]. [PDF]

open access: yesDev Cogn Neurosci
Rosenberg BM   +10 more
europepmc   +1 more source

Разработка мультиплексной ДНК-маркерной системы идентификации генов устойчивости риса к пирикуляриозу Pi -40 и Pi-b

open access: yesПолитематический сетевой электронный научный журнал Кубанского государственного аграрного университета, 2013
В результате работы разработан мультиплексный набор для идентификации генов устойчивости к пирикуляриозу Pi-40 и Pi-b. Оптимизированные комбинации праймеров и условий ПЦР позволяют безошибочно идентифицировать одновременно оба указанных гена, при постановке одной реакции.
openaire   +1 more source

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