Results 91 to 100 of about 442,345 (289)
FEBS Open Bio, EarlyView.Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata +3 more
wiley +1 more source
Validation of PI-RADS version 2 in transition zone lesions for the detection of prostate cancer
, 2018 © RSNA, 2018. Purpose: To determine the association between Prostate Imaging Reporting and Data System (PI-RADS) version 2 scores and prostate cancer (PCa) in a cohort of patients undergoing biopsy of transition zone (TZ) lesions.
Maria J. Merino +21 more
core +1 more source
Diagnostic and Interventional RadiologyPURPOSE: To evaluate magnetic resonance imaging (MRI)-targeted biopsy (MRI-TB) performance in detecting clinically significant prostate cancer (csPCa) with a Prostate Imaging Reporting and Data System (PI-RADS) score of ≥3 peripheral zone (PZ) lesions ...
Serdar Aslan +4 more
doaj +1 more source
Asian Journal of Oncology, 2019 Introduction Majority of the elderly male population suffers from prostatism due to enlargement of the prostate as a result of what is now regarded as male climacteric.
Reddy Ravikanth, Pooja Majumdar
doaj +1 more source
Characterizing Cutaneous α‐Synuclein Deposition and Seeding Activity in Parkinson's Disease Subtypes
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Cutaneous phosphorylated α‐synuclein (p‐syn) and α‐synuclein seeding activity are promising biomarkers for Parkinson's disease (PD), but their clinical value remains uncertain due to disease heterogeneity. This study evaluates these two biomarkers in PD patients to inform phenotype‐specific diagnosis and disease severity assessment ...
Yuting Jin +8 more
wiley +1 more source
Diagnostic Performance of MP-MRI with PI-RADS.
, 2015 MP-MRI: multiparametric magnetic resonance imaging; PI-RADS: Prostate Imaging Reporting and Data System; PSA: prostate specific antigen; AUC: areas under the curve; ROC: receiver operating characteristic; CI: confidence interval; PPV: positive predictive
He Wang (250350) +8 more
core +1 more source
Buletinul Academiei de Ştiinţe a Moldovei: Ştiinţe MedicaleCancerul de prostată este una dintre cele mai frecvente neoplazii diagnosticate la bărbați. Determinarea PSA-ului este un pas important în depistarea precoce, însă evaluarea imagistică prin RMN multiparametric, utilizând scorul PI- RADS, oferă o ...
Емиль ЧЕБАН +2 more
doaj +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Hereditary Spastic Paraplegia (HSP) comprises a group of rare genetic diseases characterized by length‐dependent axonal degeneration of the corticospinal tracts and dorsal columns, whose main clinical feature is spastic gait. Pathogenic variants in the SPG4 gene cause Spastic Paraplegia Type 4 (SPG4‐HSP), the most common form of HSP.
Gaia Fattorini +12 more
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Progression independent of relapse activity is a major determinant of long‐term disability in multiple sclerosis, but its immunopathologic basis remains incompletely understood. We investigated whether relapse‐independent progression in radiologically stable relapsing–remitting multiple sclerosis is associated with distinct ...
Antonio Bruno +19 more
wiley +1 more source
Clinical, Histologic, and Serological Predictors of Renal Function Loss in Lupus Nephritis
Arthritis Care &Research, EarlyView.Objective Kidney survival is the ultimate goal in lupus nephritis (LN) management, but long‐term predictors remain inadequately studied, requiring long‐term follow‐up. This study aimed to identify baseline and early longitudinal predictors of kidney survival in the Accelerating Medicines Partnership LN longitudinal cohort.
Shangzhu Zhang +21 more
wiley +1 more source