Results 151 to 160 of about 747,789 (272)
Literatura y LingüísticaEste trabajo analiza la traducción de términos del ámbito jurídico chileno al mapuzugun, lengua indígena con mayor número de hablantes en el estado de Chile. En particular, examina las técnicas de traducción de 75 términos jurídicos, extraídos de 30 textos bilingües español-mapuzugun, con el doble objetivo de examinar en qué medida la traducción de un ...
Belén Villena Araya +1 more
openaire +1 more source
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
From tumor‐centric to ecosystem‐based hypotheses in brain tumor research and care
Molecular Oncology, EarlyView.Primary brain tumors, whether in adults or children, present a major challenge because of their dramatic prognosis and the ongoing lack of efficient therapeutic approaches. In recent years, a shift has occurred from tumor‐centric concepts to a more holistic view of these tumors as dynamic ecosystems.
Julie Gavard +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach +9 more
wiley +1 more source
FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source
Molecular Evolution and Related Defense Response of Pi-ta Gene in Wild Rice (Oryza rufipogon)
, 2013 Pi-ta為水稻抗病（R）蛋白質，可專一性的辨識稻熱病病原菌的致病因子AVRpita，啟動抗病反應。此研究分析36個亞洲野生稻O. rufipogon的Pi-ta基因序列，經排列比較的結果，可以分成兩類基因群：H1及H2；藉由與外群非洲野生稻O. barthii比較，可推論H1衍生自H2。已知Pi-ta的第918胺基酸為決定對AVRpita的辨識專一性，由最大似然樹的結果，H1與水稻的Pi-ta分在同一個支序內，在第918胺基酸同樣為具有抗病性的丙胺酸，而H2則全都為不具抗病性的絲胺酸 ...
黃俊霖, Huang, Chun-Lin
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