Results 161 to 170 of about 1,063,869 (264)

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Kappa Pi Constitution

The Kappa Pi Constitution ...
Kappa Pi National Fraternity
core   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

A programmed reset mechanism primes <i>Clostridioides difficile</i> virulence at the onset of infection. [PDF]

Sci Adv
Gadda NC, Santos-Santiago JA, Sellers RS, Tamayo R.   +3 more
europepmc   +1 more source

Study and design of a PI controller for voltage regulation on a buck converter.

reservedla tesi si studieranno un caso diverso del controllore PI che abbiamo già visto in laboratorio didattico la cui risposta al gradino sarà diversa. useremo quindi questo circuito per il controllo di tensione del circuito step-down "buck". visione
BOESSO, SEBASTIANO
core  

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Natural variation in the atypical resistance gene Ptr confers broad-spectrum neck blast resistance in rice. [PDF]

Plant Genome
Navea IP, Monsur MA, Telebanco-Yanoria MJ, De La Rosa DG, Hechanova SL, Tuaño AP, Cumagun CJ, Choi IR, Kadaru S, Kim SR, Zhou B, Schepler-Luu V.   +11 more
europepmc   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Cellular and functional dissection of the octopaminergic and tyraminergic system in the Drosophila brain. [PDF]

Curr Biol
Palacios Castillo LM, Fajner V, Yalbir E, Shahul S, Ruff B, Lee VJ, Koger A, Heller J, Ishii K, Morad V, Trask M, Warren C, Frighetto G, Frye MA, Asahina K.   +14 more
europepmc   +1 more source