Results 181 to 190 of about 59,268 (267)

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Typhoon-related Leptospirosis and Melioidosis, Taiwan, 2009

Emerging Infectious Diseases, 2011
Hsun-Pi Su, Ta-Chien Chan, Chao-Chin Chang   +2 more
doaj   +1 more source

Alpha-Pinene and Tannic Acid Inhibit Trichomonas vaginalis Protozoan Cells by Inducing Apoptosis

Iranian Journal of Parasitology
Background: Trichomoniasis is one of the most common sexually transmitted infections worldwide. The growing concern of drug resistance of this infection has cautioned the need for new drug development.
Masoumeh Moradi, Dara Dastan, Mohammad Fallah, Manizhe Kashi Nahanji, Mohammad Matini   +4 more
doaj  

Hydrated metal charge density as a universal descriptor explaining mechanistic variations in periodate activation toward pollutant degradation. [PDF]

Nat Commun
Qian Y, Sun Y, Xu J, Gao P, Xue G, Zhou X, Zhang Y, Chen J.   +7 more
europepmc   +1 more source

Establishment and Application of Multiplex PCR System for Two Blast Resistance Genes Pi-ta and Pi-b in Rice

Acta Agronomica Sinica, 2014
Shu YAO, Yan-Qing LIU, Ya-Dong ZHANG, Zhen ZHU, Tao CHEN, Qing-Yong ZHAO, Li-Hui ZHOU, Chun-Fang ZHAO, Xin YU, Cai-Lin WANG   +9 more
openaire   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Zinc peroxide-copper bimetallic nanozyme with self-activated ROS and cuproptosis for superficial antifungal therapy. [PDF]

J Nanobiotechnology
Chen F, Ye Y, Yao Y, He J, Yu X, Zhang R, Ailifeire H, Luo C, Yao K, Tang X, Shentu X.   +10 more
europepmc   +1 more source

Dundee Discussion Papers in Economics 103:The illusions, reality and implications of British government expenditure 1948- 1968 [PDF]

, 1999
Morelli, Carlo J.
core  

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Factors Associated with Pressure Injury Occurrence in Older Trauma Patients. [PDF]

Healthcare (Basel)
Kim M, Choi S.
europepmc   +1 more source