Results 81 to 90 of about 59,033 (267)

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Characteristics of Esophageal Cancer Cases in Tanzania. [PDF]

, 2017
PurposeAge-standardized incidence rates for esophageal cancer (EC) in East Africa have been reported as disproportionately high compared with the worldwide incidence of nine per 100,000 population.
Deardorff, Katrina V, Hiatt, Robert A, Merritt, Megan, Mgisha, William, Mmbaga, Elia J, Mushi, Beatrice, Mwaiselage, Julius, Van Loon, Katherine, Zhang, Li   +8 more
core   +2 more sources

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

The role of the emergency department in the management of acute heart failure: an international perspective on education and research [PDF]

, 2015
Emergency departments are a major entry point for the initial management of acute heart failure (AHF) patients throughout the world. The initial diagnosis, management and disposition - the decision to admit or discharge - of AHF patients in the emergency
Bueno, Hector, Collins, Sean P, DI SOMMA, Salvatore, Diercks, Deborah B, Gray, Alasdair, Harjola, Veli Pekka, Hollander, Judd E, Lambrinou, Ekaterini, Levy, Phillip D, Miró, Òscar, Möckel, Martin, Pang, Peter S, Papa, Annmarie   +12 more
core   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

A novel thermal acoustic device based on porous graphene

AIP Advances, 2016
A thermal acoustic (TA) device was fabricated by laser scribing technology. Polyimide (PI) can be converted into patterned porous graphene (PG) by laser’s irradiation in one step. The sound pressure level (SPL) of such TA device is related to laser power.
Lu-Qi Tao, Ying Liu, He Tian, Zhen-Yi Ju, Qian-Yi Xie, Yi Yang, Tian-Ling Ren   +6 more
doaj   +1 more source

Implementation of a Feedback I2-Controlled Constant Temperature Environment Temperature Meter

Sensors, 2003
A feedback thermo-resistive sensor-based measurement scheme was proposed to estimate physical quantities like solar radiation (H), fluid velocity (U) and environment temperature (Ta).
Raimundo C. S. Freire, Marcos E. P. V. Zurita, Cleber V. R. Almeida, Antônio Q. Andrade, Alexandre S. Costa, Amauri Oliveira, Lígia S. Palma   +6 more
doaj   +1 more source

Predicting suicides after outpatient mental health visits in the Army Study to Assess Risk and Resilience in Servicemembers (Army STARRS). [PDF]

, 2017
The 2013 US Veterans Administration/Department of Defense Clinical Practice Guidelines (VA/DoD CPG) require comprehensive suicide risk assessments for VA/DoD patients with mental disorders but provide minimal guidance on how to carry out these ...
Army STARRS Collaborators, Bliese, P, Bossarte, RM, Bromet, EJ, Fullerton, CS, Gilman, SE, Ivany, C, Kessler, RC, Lewandowski-Romps, L, Millikan Bell, A, Naifeh, JA, Nock, MK, Petukhova, MV, Reis, BY, Rosellini, AJ, Sampson, NA, Stein, MB, Ursano, RJ, Zaslavsky, AM   +18 more
core   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source