Results 241 to 249 of about 261,386 (249)

Clinical, epidemiologic, and pulmonary function studies in alpha,-antitrypsin-deficient subjects of Pi Z type.

The American review of respiratory disease, 1977
The results of pulmonary function testing and systematic medical history and epidemiologic data collection are reported for 20 persons with alpha 1-antitrypsin deficiency of Pi Z phenotype. The most common symptom, reported in 19 subjects (95 per cent), was dyspnea on exertion; 16 subjects (80 per cent) gave a history of wheezing, and 8 (40 percent ...
W, Rawlings, P, Kreiss, D, Levy, B, Cohen, H, Menkes, S, Brashears, S, Permutt   +6 more
openaire   +1 more source

High-Speed Detection of α1-Antitrypsin Deficiency Alleles Pi*S and Pi*Z on the LightCycler

2001
Protease inhibitor 1 (αl-antitrypsin, AT) is the main serum inhibitor of proteolytic enzymes. In AT-deficiency, enzymes such as neutrophil elastase can damage the lung tissues, leading to pulmonary emphysema. More than 90 different alleles have been identified so far for the protease inhibitor 1 (PI) gene.
Charalampos Aslanidis, Gerd Schmitz
openaire   +1 more source

Sa1540 THE IMPACT OF A1-ANTITRIPSIN DEFICIENCY AND PI*Z ALLELE IN LIVER FIBROSIS

Gastroenterology, 2023
Ana Isabel Ferreira, Tiago Lima Capela, Sofia Xavier, Joana Magalhães, Catarina Guimarães, Carla M. Marinho, José Cotter   +6 more
openaire   +1 more source

Alpha-1 antitrypsin deficiency and Pi*S and Pi*Z SERPINA1 variants are associated with asthma exacerbations

2023
Introduction and objectives: Asthma is a chronic inflammatory disease of the airways. Asthma patients may experience potentially life-threatening episodic flare-ups, known as exacerbations, which may significantly contribute to the asthma burden. The Pi*S and Pi*Z variants of the SERPINA1 gene, which usually involve alpha-1 antitrypsin (AAT) deficiency,
Martín-González, Elena, Hernández-Pérez, José M., Pérez Pérez, José A., Perez-Garcia, Javier, Herrera-Luis, Esther, González-Pérez, Ruperto, González-González, Orelvis, Mederos-Luis, Elena, Sánchez-Machín, Inmaculada, Poza-Guedes, Paloma, Sardón, Olaia, Corcuera, Paula, Cruz, María Jesús, González-Barcala, Francisco J., Martínez Rivera, Carlos, Mullol, Joaquim, Muñoz Gall, Xavier, Olaguibel, José M., Plaza, Vicente, Quirce Gancedo, Santiago, Valero, Antonio, Sastre, Joaquín, Korta-Murua, Javier, del Pozo, Victoria, Lorenzo-Díaz, Fabián, Villar, Jesús, Pino-Yanes, María, González-Carracedo, M.A., Universitat Autònoma de Barcelona   +28 more
openaire   +1 more source

PCR genotyping of the two common alpha1 antitrypsine deficiency alleles Pi Z and Pi S

1997
alpha1-antitrypsin is important protease inhibitor . The gene is located on chromosome 14. Some deficiency alleles are associated with low levels of alpha1-antitrypsin in serum and can either be linked to liver disease and/or to early onset emphysema. The most common deficiency allele are Pi Z (single base substitution in exon 5) and Pi S (single base ...
Štefanović, Mario, Topić, Elizabeta, Žuntar, Irena   +2 more
openaire   +1 more source

Alpha-1-Antitrypsin Deficiency PI*Z Genotype Distribution in the USA.

B62. ALPHA-1 ANTITRYPSIN: MOLECULAR, EPIDEMIOLOGICAL, AND CLINICAL FEATURES IN 2009, 2009
A Tonelli, FN Rouhani, N Viranovskaya, P Schreck, LR Bridges, C Charleston, B Min, M Brantly   +7 more
openaire   +1 more source

DNA haplotyping of PI Z and M alleles within the German population.

American journal of human genetics, 1989
C, Meisen, W, Poller, K, Olek
openaire   +1 more source

Orodje za dimenzioniranje dog osnovano na aproksimaciji pi z razmerjem 22:7:

1976
Kolenc, Jure, Kurent, Tine, Marinko, Anton, Marinko, Jože   +3 more
openaire   +1 more source

IDENTIFICATION OF THE PI-Z BLAST RESISTANCE GENE IN RICE SAMPLES USING MARKER ANALYSIS METHOD

INNOVATIVE DEVELOPMENT OF THE AGRO-INDUSTRIAL COMPLEX: NEW APPROACHES AND RELEVANT RESEARCH
openaire   +1 more source