Results 131 to 140 of about 4,298,011 (325)
Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn +11 morewiley +1 more sourceRecurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa +15 morewiley +1 more sourcePeroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski +17 morewiley +1 more sourceStudy of B0 -> D*- pi+ pi- pi+ and B0 -> D*- K+ pi- pi+ decays
, 2013 Comment: 12 pages, 2 ...LHCb collaboration, Aaij, R., Beteta, C. Abellan, Adametz, A., Adeva, B., Adinolfi, M., Adrover, C., Affolder, A., Ajaltouni, Z., Albrecht, J., Alessio, F., Alexander, M., Ali, S., Alkhazov, G., Cartelle, P. Alvarez, Alves Jr, A. A., Amato, S., Amhis, Y., Anderlini, L., Anderson, J., Andreassen, R., Appleby, R. B., Gutierrez, O. Aquines, Archilli, F., Artamonov, A., Artuso, M., Aslanides, E., Auriemma, G., Bachmann, S., Back, J. J., Baesso, C., Balagura, V., Baldini, W., Barlow, R. J., Barschel, C., Barsuk, S., Barter, W., Bauer, Th., Bay, A., Beddow, J., Bediaga, I., Belogurov, S., Belous, K., Belyaev, I., Ben-Haim, E., Benayoun, M., Bencivenni, G., Benson, S., Benton, J., Berezhnoy, A., Bernet, R., Bettler, M. -O., van Beuzekom, M., Bien, A., Bifani, S., Bird, T., Bizzeti, A., Bjørnstad, P. M., Blake, T., Blanc, F., Blanks, C., Blouw, J., Blusk, S., Bobrov, A., Bocci, V., Bondar, A., Bondar, N., Bonivento, W., Borghi, S., Borgia, A., Bowcock, T. J. V., Bowen, E., Bozzi, C., Brambach, T., Brand, J. van den, Bressieux, J., Brett, D., Britsch, M., Britton, T., Brook, N. H., Brown, H., Burducea, I., Bursche, A., Buytaert, J., Cadeddu, S., Callot, O., Calvi, M., Gomez, M. Calvo, Camboni, A., Campana, P., Carbone, A., Carboni, G., Cardinale, R., Cardini, A., Carranza-Mejia, H., Carson, L., Akiba, K. Carvalho, Casse, G., Cattaneo, M., Cauet, Ch., Charles, M., Charpentier, Ph., Chen, P., Chiapolini, N., Chrzaszcz, M., Ciba, K., Vidal, X. Cid, Ciezarek, G., Clarke, P. E. L., Clemencic, M., Cliff, H. V., Closier, J., Coca, C., Coco, V., Cogan, J., Cogneras, E., Collins, P., Comerma-Montells, A., Contu, A., Cook, A., Coombes, M., Coquereau, S., Corti, G., Couturier, B., Cowan, G. A., Craik, D., Cunliffe, S., Currie, R., D'Ambrosio, C., David, P., David, P. N. Y., De Bonis, I., De Bruyn, K., De Capua, S., De Cian, M., De Miranda, J. M., De Paula, L., De Silva, W., De Simone, P., Decamp, D., Deckenhoff, M., Degaudenzi, H., Del Buono, L., Deplano, C., Derkach, D., Deschamps, O., Dettori, F., Di Canto, A., Dickens, J., Dijkstra, H., Dogaru, M., Bonal, F. Domingo, Donleavy, S., Dordei, F., Suárez, A. Dosil, Dossett, D., Dovbnya, A., Dupertuis, F., Dzhelyadin, R., Dziurda, A., Dzyuba, A., Easo, S., Egede, U., Egorychev, V., Eidelman, S., van Eijk, D., Eisenhardt, S., Eitschberger, U., Ekelhof, R., Eklund, L., Rifai, I. El, Elsasser, Ch., Elsby, D., Falabella, A., Färber, C., Fardell, G., Farinelli, C., Farry, S., Fave, V., Ferguson, D., Albor, V. Fernandez, Rodrigues, F. Ferreira, Ferro-Luzzi, M., Filippov, S., Fitzpatrick, C., Fontana, M., Fontanelli, F., Forty, R., Francisco, O., Frank, M., Frei, C., Frosini, M., Furcas, S., Furfaro, E., Torreira, A. Gallas, Galli, D., Gandelman, M., Gandini, P., Gao, Y., Garofoli, J., Gersabeck, E., Gligorov, V. V., Graugés, E., He, J., Hoballah, M., Koppenburg, P., Lafferty, G., Latham, T., Gac, R. Le, Lefèvre, R., Leroy, O., Martinelli, M., Santos, D. Martinez, Massafferri, A., Nasteva, I., Needham, M., Orlandea, M., Parkinson, C. J., Perazzini, S., Perrin-Terrin, M., Petrolini, A., Phan, A., Casasus, M. Plo, Poluektov, A., Potterat, C., Navarro, A. Puig, Rangel, M. S., Raven, G., Rodrigues, E., Sarti, A., Schiller, M., Schmelling, M., Schneider, O., Sciascia, B., Serra, N., Serrano, J., Seyfert, P., Shears, T., Souza, D., Steinkamp, O., Stone, S., van Tilburg, J., Tisserand, V., Tonelli, D., Gomez, R. Vazquez, Regueiro, P. Vazquez, Watson, N. K., Yang, Z., Zhang, Y. +248 moreopenaire +4 more sourcesDammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh +8 morewiley +1 more source
