Results 111 to 120 of about 390,020 (313)

RNA virus modulation of IFN, PI3K and apoptosis

, 2009
Interferon (IFN) and phosphatidylinositol 3-kinase (PI3K) are apoptosis regulators that are targeted by viruses to promote survival of infected cells.
Killip, Marian J.
core  

Sonic Hedgehog Signaling Contributes to Chronic Post-Thoracotomy Pain via Activating BDNF/TrkB Pathway in Rats

Journal of Pain Research, 2020
Yitian Yang,1,* Xiaoyan Wang,2,* Xuan Zhang,3 Shaohua You,1 Long Feng,1 Yunliang Zhang,1 Yizheng Shi,1 Yuhai Xu,4 Hong Zhang1 1Anesthesia and Operation Center, The First Medical Center of Chinese PLA General Hospital, Medical School of Chinese PLA ...
Yang Y, Wang X, Zhang X, You S, Feng L, Zhang Y, Shi Y, Xu Y, Zhang H   +8 more
doaj  

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

Immunoblotting analyzes of protein expression of IGF-1-PI3K-AKT-mTOR pathway from gastrocnemius muscle.

, 2018
The protein levels of GAPDH shown at the bottom of each immunoblot were used to normalize by the protein levels of each immunoblot shown at the top. Three independent experiments are shown and separated according to the treatment, indicated with a color ...
Eduardo José Caldeira (5819066), Renato Ferretti (5819057), Eliezer Guimarães Moura (5819060), Matias Mosqueira (162817), Veridiana Carvalho dos Santos (5819063), Cintia Yuri Matsumura (423318), Adriana Pertille (755906), Marcelo Conte (5819069)   +7 more
core   +1 more source

PI3Ks in Lymphocyte Signaling and Development [PDF]

, 2010
Lymphocyte development and function are regulated by tyrosine kinase and G-protein coupled receptors. Each of these classes of receptors activates phosphoinositide 3-kinase (PI3K). In this chapter, we summarize current understanding of how PI3K contributes to key aspects of the adaptive immune system.
Klaus, Okkenhaug, David A, Fruman
openaire   +2 more sources

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

The IGF1-PI3K-Akt signaling pathway in mediating exercise-induced cardiac hypertrophy and protection

, 2017
The IGF1-PI3K-Akt signaling pathway in mediating exercise-induced cardiac hypertrophy and ...
JYY Ooi (16215323), KL Weeks (13966968), BC Bernardo (10669524), NL Patterson (16215467), JR McMullen (14535023)   +4 more
core  

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

Editorial for the Research Topic "Targeting PI3K/mTOR signaling in cancer" [PDF]

, 2014
The phosphatidylinositol 3-kinase (PI3K)/mTOR pathway integrates signals from growth factors with nutrient signals and other conditions and controls multiple cell responses, including proliferation, survival and metabolism.
Alexandre Arcaro, Arcaro, Alexandre, Alexandre eArcaro   +2 more
core   +1 more source

Dual inhibition of PI3K and mTOR by VS-5584 suppresses thrombus formation

Platelets, 2018
VS-5584 is a highly selective dual kinase inhibitor which suppresses phosphatidylinositol 3-kinase (PI3K) and mammalian target of rapamycin (mTOR) activity.
Thomas Später, Isabelle Müller, Hermann Eichler, Michael D. Menger, Matthias W. Laschke, Emmanuel Ampofo   +5 more
doaj   +1 more source