Results 91 to 100 of about 428,204 (309)
Effects of water-soluble tomato concentrate on platelet aggregation
World Journal of Traditional Chinese Medicine, 2019 Objective: To investigate the antiplatelet aggregation effect of water-soluble tomato concentrate (WSTC) and explore the underlying molecular mechanisms.
Qian Zhang +11 more
doaj +1 more source
, 2015 In the liver, insulin-mediated activation of the phosphatidylinositol 3-kinase (PI3K)/Akt pathway is at the core of metabolic control. Multiple PI3K and Akt isoenzymes are found in hepatocytes and whether isoform-selective interplays exist is currently ...
C. Campa (23549569) +15 more
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, 2022 Natural killer (NK) cells perform immune surveillance functions in tumors. The antitumor effects of NK cells are closely related to tumor occurrence and development.
Lei Zhou (19808) +11 more
core +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Novel PI3K and mTOR selective inhibitors to deconvolute PI3K signaling
, 2021 Phosphoinositide 3-kinase (PI3K) signaling has key roles in the regulation of cellular processes such as cell growth, proliferation, and metabolism. Constitutive activation of PI3K in tumors is frequent and drives cancer progression.
Keles, Erhan
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Targeting PI3K in cancer: any good news? [PDF]
, 2013 The phosphatidylinositol 3-kinase (PI3K) signaling pathway regulates several cellular processes and it’s one of the most frequently deregulated pathway in human tumors.
Gulluni, Federico +11 more
core +1 more source
Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source
Cancer Management and Research, 2021 Hongmei Zhong,1– 4 Guilin Zeng,2– 4 Lang He2– 4 1Chengdu University of Traditional Chinese Medicine, Chengdu, 610075, Sichuan Province, People’s Republic of China; 2Department of Oncology, The Fifth People’s Hospital of Chengdu, Chengdu, 611130, Sichuan ...
Zhong H, Zeng G, He L
doaj
USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival
Molecular Oncology, EarlyView.CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna +8 more
wiley +1 more source
, 2010 Cell migration is essential for wound healing, the immune response, embryogenesis, and cancer metastasis. Chemotaxis, or cell migration directed by an external gradient of chemoattractant, is encountered in various physiological and natural settings and
Melvin, Adam Thomas
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