Results 301 to 310 of about 626,720 (343)
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Targeting PI3K in neuroblastoma
Journal of Cancer Research and Clinical Oncology, 2010This work employs pharmacological targeting of phosphoinositide 3-kinases (PI3K) in selected neuroblastoma (NB) tumors with the inhibitor AS605240, which has been shown to express low toxicity and relative specificity for the PI3K species γ.The expression pattern of PI3K isoforms in 7 NB cell lines and 14 tumor patient samples was determined by Western
Spitzenberg, Volker +11 more
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PI3K pathway in prostate cancer: All resistant roads lead to PI3K
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2018The phosphoinositide 3-kinase (PI3K) pathway integrates multifarious environmental cues to regulate cell survival, growth, and metabolism. Hyperactivation of the PI3K pathway increases biological fitness by offering a high degree of adaptability to and resilience against diverse perturbations, thus conferring survival benefits on premalignant and ...
Soonbum, Park +4 more
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Gan to kagaku ryoho. Cancer & chemotherapy, 2011
PI3K-Akt is an important signal transduction pathway which acts downstream from various growth factor receptors. The PI3K-Akt pathway is activated in many types of cancers by several mechanisms, including growth factor receptor activation, loss of PTEN, and PI3K gene mutations. Therefore, PI3K is thought to be an ideal therapeutic target.
Seiji, Yano +6 more
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PI3K-Akt is an important signal transduction pathway which acts downstream from various growth factor receptors. The PI3K-Akt pathway is activated in many types of cancers by several mechanisms, including growth factor receptor activation, loss of PTEN, and PI3K gene mutations. Therefore, PI3K is thought to be an ideal therapeutic target.
Seiji, Yano +6 more
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2010
PI3Ks play important roles in the signaling pathways used by a wide variety of cell surface receptors on neutrophils. Class IB PI3K plays a major role in the initial generation of PtdIns(3,4,5)P₃ by Gi-coupled G-protein coupled receptors (GPCRs) (e.g., receptors for fMLP, C5a, LTB₄). Class IA PI3Ks generate PtdIns(3,4,5)P₃ downstream of receptors which
Phillip T, Hawkins +3 more
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PI3Ks play important roles in the signaling pathways used by a wide variety of cell surface receptors on neutrophils. Class IB PI3K plays a major role in the initial generation of PtdIns(3,4,5)P₃ by Gi-coupled G-protein coupled receptors (GPCRs) (e.g., receptors for fMLP, C5a, LTB₄). Class IA PI3Ks generate PtdIns(3,4,5)P₃ downstream of receptors which
Phillip T, Hawkins +3 more
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Science, 2007
Structural information about an enzyme implicated in numerous cancers provides insights into to how certain mutations promote cancer cell growth and survival.
Jennifer Y. Lee +2 more
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Structural information about an enzyme implicated in numerous cancers provides insights into to how certain mutations promote cancer cell growth and survival.
Jennifer Y. Lee +2 more
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PI3K Inhibitor–Induced Insulin Feedback Activates PI3K Signaling
Cancer Discovery, 2018Abstract Hyperinsulinemia drives resistance to PI3Kα inhibitors in tumors.
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Role of PI3K/Akt signaling pathway in cardiac fibrosis
Molecular and Cellular Biochemistry, 2021Wuming Qin, Linghui Cao, I. Massey
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Science Signaling, 2012
During the starvation response, the IκB kinase IKK phosphorylates the regulatory subunit of PI3K, thus inhibiting PI3K activity.
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During the starvation response, the IκB kinase IKK phosphorylates the regulatory subunit of PI3K, thus inhibiting PI3K activity.
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