Results 41 to 50 of about 728 (177)

The other side of platform politics. Law‐making and online participatory democracy in the Five Star Movement

Swiss Political Science Review, Volume 31, Issue 1, Page 14-33, March 2025.
Abstract Between 2013 and 2021, the Italian Five Star Movement implemented an advanced tool, Lex Eletti, to enhance citizens' online participation in law‐making. Elected representatives had to present their draft bills on the party's platform before introducing them in Parliament, allowing ordinary party members to discuss them and suggest ...
Filippo Tronconi, Francesco Bailo
wiley   +1 more source

A Distinctive Type of Mosaic Variegated Aneuploidy: Case Report and Review of the Literature

American Journal of Medical Genetics Part A, Volume 197, Issue 2, February 2025.
ABSTRACT Mosaic variegated aneuploidy (MVA) is an autosomal recessive disorder characterized by mosaic aneuploidies, predominantly trisomies, involving multiple different chromosomes and tissues. The proportion of aneuploid cells varies, and most patients present with intrauterine growth delay, microcephaly, and a broad spectrum of congenital ...
Annalisa Frattini, Giovanni Micheloni, Antonio Musio, Marika Bini Antunes, José Barbot, Emília Costa, Patricia Seabra, Rossana Righi, Francesco Orsini, Giuseppe Montalbano, Francesco Acquati, Giovanni Porta, Francesco Pasquali, Roberto Valli   +13 more
wiley   +1 more source

Un'esperienza portoghese di formazione dei docenti sulle ICT

Italian Journal of Educational Technology, 2008
Descrizione del problema della formazione dei docenti nel settore TIC, con particolare riferimento ad un’esperienza portoghese basata sulla formazione a distanza utilizzando la piattaforma Moodle.
Isabel Pedrosa
doaj   +1 more source

Prodrug Approach to Exploit (S)‐Alanine Amide as Arginine Mimic Moiety in the Development of Protein Arginine Methyltransferase 4 Inhibitors

ChemMedChem, Volume 19, Issue 17, September 2, 2024.
Starting from a PRMT4 inhibitor featuring the alanine amide moiety as arginine mimic, computational studies and structural manipulations yielded derivatives with adequate in vitro potency against the recombinant enzyme and good physicochemical properties, but not cell active.
Ciro Milite, Giuliana Sarno, Ida Pacilio, Agostino Cianciulli, Monica Viviano, Giulia Iannelli, Erica Gazzillo, Alessandra Feoli, Alessandra Cipriano, Maria Giovanna Chini, Sabrina Castellano, Giuseppe Bifulco, Gianluca Sbardella   +12 more
wiley   +1 more source

Challenges of enzyme therapy: Why two players are better than one

WIREs Nanomedicine and Nanobiotechnology, Volume 16, Issue 4, July/August 2024.
Therapeutic enzymes show several advantages, but face challenges linked to their physico‐chemical properties that can be solved by nanomedicine. Combining enzymes with other therapeutics in a single nanocarrier enables synergistic action, reaching a more effective therapy. Abstract Enzyme‐based therapy has garnered significant attention for its current
Sabrina Cuoghi, Riccardo Caraffi, Alessandro Anderlini, Cecilia Baraldi, Elena Enzo, Maria Angela Vandelli, Giovanni Tosi, Barbara Ruozi, Jason Thomas Duskey, Ilaria Ottonelli   +9 more
wiley   +1 more source

Collaborare online nella scuola superiore: compiti, ruoli, motivazioni

Italian Journal of Educational Technology, 2011
Una esperienza di collaborazione a distanza fra tre classi quinte di liceo scientifico, implementata su una piattaforma Moodle nell’ambito del progetto di ricerca in nota, viene presentata e confrontata con altre due, svolte a margine del progetto e ...
Maria Reggiani
doaj   +1 more source

A Runoff‐On‐Grid Approach to Embed Hydrological Processes in Shallow Water Models

Water Resources Research, Volume 60, Issue 7, July 2024.
Abstract Catchment‐scale hydrological models encountered dichotomies with the numerical hydrodynamic models when describing surface routing process. We propose a new modeling framework, the so‐called “Runoff‐On‐Grid” approach, for embedding distributed process‐based hydrological modeling into shallow water models, as an alternative to the traditional ...
Pasquale Perrini, Luis Cea, Francesco Chiaravalloti, Salvatore Gabriele, Salvatore Manfreda, Mauro Fiorentino, Andrea Gioia, Vito Iacobellis   +7 more
wiley   +1 more source

DMSO‐Related Effects on Ligand‐Binding Properties of Lysine Methyltransferases G9a and SETD8

ChemBioChem, Volume 25, Issue 4, February 16, 2024.
DMSO effects on protein–ligand affinity. Using two lysine methyltransferases (G9a/KMT1 C and SETD8/KMT5 A) and different orthogonal biophysical methods, Differential Scanning Fluorimetry (DSF), microscale thermophoresis (MST), and surface plasmon resonance (SPR), we demonstrated that the effects of DMSO are protein‐ and technique‐dependent and cannot ...
Alessandra Feoli, Giuliana Sarno, Sabrina Castellano, Gianluca Sbardella   +3 more
wiley   +1 more source

Il ruolo delle tecnologie nel tirocinio per la formazione di educatori

Italian Journal of Educational Technology, 2000
Descrizione del ruolo svolto delle tecnologie didattiche nel tirocinio del corso di laurea in Scienza della Formazione presso L’Universita’ di Firenze.
Giovanni Bonaiuti
doaj   +1 more source

GeoExt per sviluppare applicazioni WebGIS per sviluppare applicazioni WebGIS

GEOmedia, 2012
L'evoluzione degli strumenti per la realizzazione di portali WebGIS ha visto l'avvicendarsi di due  fasi e una crescente utilizzazione delle tecnologie.
Luca Delucchi
doaj   +2 more sources